摘要
目的:研究罗汉果甜苷(Mog)对实验性肝损伤小鼠的保护作用。方法:以四氯化碳诱导小鼠急性肝损伤;以卡介苗(BCG)加脂多糖(LPS)诱导小鼠免疫性肝损伤。检测血清中谷丙胺酸氨基转移酶(ALT)、谷草胺酸氨基转移酶(AST)的活性;检测肝组织中超氧化物歧化酶(SOD)的活性和丙二醛(MDA)的含量;并进行病理学检查。结果:Mog小鼠对急性、免疫性肝损伤,有降低血清中ALT、AST活性的作用;对免疫性肝损伤的肝组织匀浆有升高SOD活性、降低MDA含量的作用;并能显著减轻肝组织病理变化程度。结论:Mog对小鼠急性肝损伤、免疫性肝损伤有保护作用,其机制可能与Mog的抗脂质过氧化作用有关。
OBJECTIVE： To study the protective effect of Mogrosides on experimental liver injury in mice. METHODS： Acute hepatic injury model was induced by CCh in mice, and the immunological hepatic injury model was induced in mice by bacillus calmette- guerin （BCG） and lipopolysaccharide （LPS）. The activities of ALT and AST in serum, SOl） activity in liver tissue and content of MDA in the liver tissue were investigated; and the histological changes of liver were observed. RESULTS： Mogroside could decrease the serum activities of ALT and AST in mice with acute hepatic injury or immunological hepatic injury, increase the activity of SOD but decrease MDA content in liver tissue of mice with immunological hepatic injury, and it could lessen the histological changes of liver. CONCLUSION： Mogroside showed protective effect on mice with acute hepatic injury or immunological hepatic injury. The mechanism might be attributed to its action against lipid peroxidation.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第3期163-165,共3页
China Pharmacy
基金
广西省自然科学基金项目资助课题(桂科自0229042)
关键词
罗汉果甜苷
急性肝损伤
免疫性肝损伤
实验研究
Mogroside
Acute hepatic injury
Immunological hepatic injury
Experimental study
