摘要
目的:建立突触可塑性随Ca2+浓度振荡变化而改变的数学模型。方法:用微分方程分析Ca2+浓度振荡变化对NMDA受体下游信号通路的作用,并用数学函数描述了突触可塑性的相应改变。结果:该数学模型深刻阐述了Ca2+浓度变化对突触可塑性的影响。结论:用数学模拟和电生理实验相结合,为深层次研究学习记忆提供新视角。
Objective： To construct a mathematical model of conducting the change of synaptic plasticity during calcium concentration oscillation. Methods： Differential equation was used to analyze the effect of the NMDA receptors downstream signal pathways. Mathematical function was used to illustrate the change of synaptic plasticity. Results： The model illuminated the influence to the change of synaptic plasticity. Conclusion： Math modeling should be combined with electrophysiology experiment to investigate learning and memory further.
出处
《数理医药学杂志》
2008年第1期1-3,共3页
Journal of Mathematical Medicine
