摘要
瑞芬太尼(REM)是一种新型的阿片μ受体激动剂,其特点是可被组织及血液中的非特异性酯酶快速降解,对呼吸、循环、神经系统的作用呈剂量依赖性,对肝、肾功能无损害,用于术后静脉自控镇痛安全有效,不良反应发生少。小儿术后镇痛以静脉镇痛为主,由于小儿生理特性,术后镇痛要特别重视,REM作为一种理想的麻醉性镇痛药,开辟了一种新静脉镇痛配方,但其在小儿术后静脉自控镇痛的安全性和适用性仍需要不断地深入研究。
Remifentanil is a new agonist of opioid μ-receptor. Its obvious characteristics are that it can be rapidly degraded by the blood non-specific esterase, have effect on respiratory, circulation and mervous system in dose dependent, have no damage to liver and kidney, It can be used in postoperative patient-controlled intravenous analgesia （PCIA） safely and effectively with less side effects. Intravenos analgesia is the main method for children＇ postoperative analgesia. Because of children＇ special physiology, we should pay more attendtion to children＇ PCIA. Remifentanyl as an ideal analgesic drug is developing a new preseriprtion for PCIA. But the safty and applicability of children PCIA need further studying.
出处
《医学综述》
2008年第2期295-296,共2页
Medical Recapitulate
关键词
瑞芬太尼
儿童
术后静脉自控镇痛
Remifentanil
Children
Postoperative patient controlled intravenous analgesia
