摘要
目的:应用超声心动图评定雄性Balb/c小鼠的心脏形态和功能。方法:应用13MHz线控阵超声探头检测27只Balb/c雄性小鼠心脏(周龄:5-7周),超声检测后,进行戊巴比妥麻醉处死分离左室,测量湿重。结果:获得小鼠完整2维超声心动图,并记录雄性小鼠血流动力学参数。用M型超声心动图计算左室重量与左室湿重呈线性相关:y=1.15x+3.26(r=0.80)。结论:超声心动图参数能够评定小鼠的心脏形态和功能。
To assess the parameters of cardiac structure and function of male Balb/c mice by the eehocardiography. Methods： A total of 27 male Balb/c mice（from five to seven week old） were examined with a 13-MHz transthoracic linear-array transducer, hearts were removed from mice anesthetized with Butaylone, and the left ventricular（LV） mass were weighed. Results： Complete 2-dimensional echocardiography for cardiac structure and function were obtained. Hemodynamic parameters were recorded. A correlation existed between LV weight（x） and echocardiographic LV mass（y） with the 2D guided M-mode method： y = 1.15x ＋ 3.26, （ r = 0.80）. Conclusion： Echocardiography appears to be a promising approach for noninvasively assessing LV mass and function in mice.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2007年第4期390-393,共4页
Chinese Journal of Applied Physiology
基金
国家自然科学基金资助项目(30570745)
江苏省135重点实验室资助项目(SK200205)
关键词
超声心动图
小鼠
左室重量
echocardiography
mice
left ventricular mass
