摘要
目的探讨一氧化氮(NO)在原发性高血压(EH)患者中的变化,以及与左室肥厚(LVH)的关系。方法分别选取EH有LVH患者、EH无LVH患者及正常人各30例,检测NO水平及左室重量(LVM),进行组间比较及相关分析。结果1.EH有LVH组NO水平明显低于EH无LVH组、正常对照组,EH无LVH组NO水平明显低于正常对照组;而室间隔舒张末期厚度(IVS)、左室后壁舒张末期厚度(LVPW)、LVM水平相反(P<0.01)。2.血压与NO呈负相关、与LVM呈正相关,NO与LVM呈负相关(r>0或r<0,P<0.01或<0.05)。结论NO参与了EH及LVH形成的病理生理过程。
Objective To investigate the correlation between nitric oxide （ NO ） and essential hypertension （ EH ） and left ventricular hypertrophy （LVH）. Methods NO and left ventricular mass index （LVMI） were measured in 30 patients with EH （EH group）, 30 patients with EH and LVH （EH＋LVH group）, and 30 normal controls （NC group）. The results were treated by analysis of variance and correlation. Results 1. NO level in EH ＋LVH group was lower than＇that in NC and EH groups, and it was lower in EH group than that in NC group, while LVMI level was higher in EH＋LVH group （P〈0.01）; 2. There was a negative correlation between blood pressure and NO, while there was a positive correlation between blood pressure and LVMI, and a negative correlation between NO and LVMI （P 〈 0.01 or 〈 0.05）. Conclusions NO was involved in the pathophysiological process of EH or EH＋LVH.
出处
《老年医学与保健》
CAS
2008年第4期231-232,共2页
Geriatrics & Health Care
关键词
原发性高血压
左室肥厚
一氧化氮
essential hypertension
left ventricularhypertrophy
nitric oxide
