摘要
目的探讨研究黄芪多糖(APS)对2型糖尿病大鼠的作用及对骨骼肌组织GLUT4表达的影响。方法SD大鼠随机分为:正常对照组、黄芪多糖对照组(APS组)、2型糖尿病组(TIIDM组)和2型糖尿病黄芪多糖治疗组(TIIDM+APS组),5周后测血糖、血清胰岛素和GLUT4的水平。结果TIIDM组和TIIDM+APS组血糖均高于对照组(P<0.01),TI-IDM+APS组血糖低于TIIDM组(P<0.01);各组间血胰岛素水平差别无显著性(P>0.05);TIIDM组骨骼肌组织GLUT4的表达低于对照组和TIIDM+APS组(P<0.01)。结论APS可降低TIIDM大鼠血糖水平,其机制与提高糖尿病大鼠骨骼肌中GLUT4表达有关。
Objective To investigate the effect of Astragalus polysoccharide（APS）on expression of GLUT4 in the skeletal muscle tissue of TIIDM rats. Methods SD rats were randomly divided into four groups ： normal control group, normal control plus astragalus polysoccharide group（ APS group）, TIIDM model group（ TII DM group）, diabetic model plus astragalus polysoccharide therapy group（TII DM ＋ APS group）. The expression of GLUT4 were detected. Results The levels of blood glucose of rats in TIIDM group and TII DM ＋ APS group were significantly higher than those in control group and control ＋ APS group （ P 〈 0.01 ）, and the level of blood glucose in TIIDM ＋ APS group was significantly lower than that in TIIDM group （ P 〈 0.01 ）, levels of insulin were not significandy different among these groups（P 〉 0.05）. Expressions of GLUT4 in the skeletal muscle tissues of rats in TIIDM group was significantly lower than those in both control group, control ＋ APS group and TIIDM ＋ APS group. Conclusion APS can decrease the levels of blood glucose in type Ⅱ diabetic rats, and its mechanisms might be closely related to the elevation of the level of GLUT4 in the skeletal muscle tissues of rats.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2007年第11期2652-2653,共2页
Lishizhen Medicine and Materia Medica Research
基金
湖北省教育厅重点基金资助项目(NoD200667002)
关键词
黄芪多糖
2型糖尿病
葡萄糖转运蛋白4
Astragalus polysoccharide
Type Ⅱ diabetes mellitus
Glucose Transporter 4
