摘要
目的:研究酪蛋白酶解产物(casein hydrolysate,CH)对高血压的影响。方法:酪蛋白酶解产物经过大孔树脂DA201C脱盐处理,检测了脱盐酶解产物对血管紧张素转化酶(ACE)的抑制活性和用水解物500、1000mg/kg灌胃,观察SHR大鼠血压的影响。结果:酶解产物对ACE的活性有很强的抑制作用,抑制率为80.1%;低剂量(500mg/kg)组对自发性高血压大鼠(SHR)有显著的降血压作用;高剂量(1000mg/kg)组非常显著。结论:酪蛋白酶解产物具有降血压功能。
Objective： To study the effect of casein hydrolysate （CH） on hypertensive rats. Method： Hydrolysate of casein was desalinated by macroporous adsorption resins DA201C. Angiotensin converting enzyme （ACE） inhibitory activity and antihypertensive activity of casein hydrolysate at the dose of 500, 1 000 mg/kg were measured. Results： CH had significant inhibitory activity against ACE （the inhibitory rate 80.1%）, and low concentration （500 mg/kg bw·d） had remarkable antihypertensive activity on spontaneously hypertensive rats （SHR）, and extremely remarkable at high concentration （1 000 mg/kg bw·d）. Conclusion： Casein hydrolysate showed antihypertensive activity in SHR.
出处
《营养学报》
CAS
CSCD
北大核心
2007年第5期476-478,484,共4页
Acta Nutrimenta Sinica
