摘要
目的探讨门冬氨酸钾镁对冠心病心绞痛和冠心病心律失常患者的氧化应激态及脂质氧化损伤的保护效应,及其对心律失常影响的可能机制。方法采用单盲随机原则将98例冠心病心绞痛和冠心病心律失常患者随机分为试验组（65例）和对照组（33例）。试验组在心血管疾病常规治疗基础上加用门冬氨酸钾镁,而对照组仅用心血管疾病常规治疗。两组分别在用药前和用药1周时检测血浆中还原型谷胱甘肽（GSH）、氧化型谷胱甘肽（GSSG）、丙二醛（MDA）及氧化低密度脂蛋白（ox-LDL）的含量,并连续监测24h心律。结果与对照组比较,试验组用药后1周GSH含量及GSH/GSSG比值均明显升高（P均〈0.01）,而GSSG、MDA及ox-LDL的含量均明显下降（P均〈0.01）。试验组期前收缩总数减少86.5%,对照组期前收缩总数只减少了47.4%,两组比较差异有统计学意义（P〈0.01）;且患者氧化应激态指标（GSH/GSSG比值、MDA、ox-LDL）的改善与期前收缩总数的减少呈显著的直线相关关系（P均〈0.01）。连续应用门冬氨酸钾镁1周未发现有药物不良反应事件发生。结论门冬氨酸钾镁能显著改善冠心病心绞痛和冠心病心律失常患者机体的氧化应激态,降低脂质氧化损伤程度,并对频发期前收缩有良好的治疗效应。门冬氨酸钾镁对频发期前收缩的治疗效果与其抗氧化损伤效应间具有显著的相关性,提示氧化应激可能是冠心病心律失常的发生机制之一。
Objective To investigate the protective effects of potassium magnesium aspartate against oxidative stress status and lipid oxidative damage in the patients with angina and arrhythmia due to coronary artery disease, its therapeutic effect on arrhythmia and its possible mechanism. Methods With single blind protocol, 98 patients with angina and arrhythmia due to coronary artery disease were randomly divided into ①Experiment group （n=65）, who received routine remedy for coronary heart disease plus potassium magnessium aspartate. ②Control group （n=33）, who received only routine therapy for coronary heart disease without potassium magnessium aspartate. Reduced glutathione （GSH）, oxidized glutathione （GSSG）, malondialdehyde （MDA） and oxidized low density lipoprotein （ox-LDL） in plasma of all patients were examined before and one week after treatment,all patients with arrhythmia were equipped with Holter for continuous monitoring of cardiac rhythm. Results After one week′s treatment, the GSH level in plasma of experiment group and the ratio of GSH and GSSG （GSH/GSSG） were significantly increased comparing with control group （both P〈0.01）,while GSSG, MDA and ox-LDL levels significantly lowered comparing with control group（all P〈0.01）. The premature beats diminished 86.5% in experiment group, but the decrease rate in control group was only 47.4% （P〈0.01）. The improvement in indexes of oxidative stress status （including GSH/GSSG, MDA and ox-LDL） and the reduction of premature beats showed close correlation with each other （all P〈0.01）. No adverse effects of the drug were found after one week of administration of Potassium magnessium aspartate. Conclusion Potassium magnessium aspartate can strikingly improve oxidative stress status and decrease lipid oxidative damage in the patients with coronary heart disease, and the frequent premature beats were also significantly reduced by potassium magnessium aspartate. The analysis of above results reveals an intrinsic relationship between the improvement of oxidative stress status and the good therapeutic effects on frequent premature beats by potassium magnessium aspartate, which may suggest an involvement of oxidative stress in the pathogenesis of arrhythmias.
出处
《中国危重病急救医学》
CAS
CSCD
北大核心
2007年第11期662-666,共5页
Chinese Critical Care Medicine
基金
教育部博士点基金资助项目（20050610050）
关键词
门冬氨酸钾镁
氧化应激态
谷胱甘肽
丙二醛
氧化低密度脂蛋白
potassium magnesium aspartate
oxidative stress status
glutathione
malondialdehyde
oxidized low density lipoprotein
