摘要
目的观察口服利培酮对未经治疗的首发精神分裂症患者血糖和血脂的影响。方法:对62例未经治疗的首发精神分裂症患者,给予利培酮2～6mg,1次/d,连续口服12周。于治疗前和治疗4、8、12周末,用阳性症状和阴性症状量表(PANSS)评定精神症状,用不良反应症状量表(TESS)评定不良反应,用葡萄糖氧化酶法测定血糖(Glu)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)浓度。结果:服药12周后,62例患者中22例(35.48%)患者治愈,38例(61.29%)显著好转,2例(3.23%)有效。22例(35.48%)有不良反应记录(失眠、口干、便秘、震颤和静坐不能等)。服药后第4,8,12周末的TC和TG浓度,第8周末的HDL浓度,第12周末的LDL浓度与治疗前相比差异均有统计学意义(P<0.01,P<0.05,P<0.05),Glu浓度各时段组间比较,差异均无统计学意义(P>0.05)。结论:利培酮口服可有效缓解首发精神分裂症患者的症状,不良反应较轻;利培酮对血糖无明显影响,但可使TC和TG浓度明显升高。
Objective： To observe the effects of risperidone on blood glucose and lipid in first-episode, drug-naive patients with schizophrenia. Methods： Sixty-two first-episode, drug-naive patients with schizophrenia were given risperidone 2 -6 mg once daily for 12 weeks. The mental symptoms were assessed with PANSS, adverse reactions were assessed with TESS, and blood glucose, total cholesterol （TC）, triglycerides （TG）, high-density lipoproteins （HDL）, and low-density lipoproteins （LDL） were measured with glucose oxidase methods before administration and in the end of the fourth, eighth, and twelfth week after administration. Results： Of the sixty-two patients, 22 （35.48%） were cured, 38（61.29% ） marked improved, and 2 （3.23%） responded after 12 weeks of treatment. Twenty-two patients developed adverse reactions including insomnia, dry mouth, constipation, tremor, and akathisia, The differences were statistically significant as compared TC and TG concentration in the end of the fourth, eighth, and twelfth week during treatment, HDL concentration in the end of eighth week during treatment, and LDL concentration in the end of the twelfth week during treatment with those before treatment （ P 〈 0. 01, P 〈 0. 05, P 〈 0. 05 ）. The difference as in blood glucose concentration were no statistically significant as compared before medication with after medication （ P 〉 0. 05 ）. Conclusion： Risperidone may effective relieve the symptoms of first-episode patients with schizophrenia and its adverse reactions are relatively mild. Risperidone has no effects on blood glucose, but it may obviously elevate the levels of TC and TG.
出处
《药物不良反应杂志》
2007年第5期324-328,共5页
Adverse Drug Reactions Journal
关键词
利培酮
精神分裂症
血糖
血脂
risperidone
schizophrenia
blood glucose, blood lipid
