摘要
研究复方黄芩颗粒剂对昆明小鼠免疫功能的影响。应用复方黄芩颗粒给小鼠灌胃10 d后,分别测定对照组与实验组胸腺指数、脾脏指数和血清中的免疫球蛋白IgAI、gGI、gM和补体C3、C4;并且进行体外实验,用不同浓度的复方黄芩颗粒剂对小鼠脾脏淋巴细胞进行体外培养,测定淋巴细胞转移刺激指数(SI);在体外培养测定细胞吞噬中性红的能力。与对照组相比,试验组的胸腺指数、脾脏指数、免疫球蛋白和补体C3、C4都升高且显著水平为差异显著(P<0.05);脾脏淋巴细胞转移刺激指数均极显著地高于对照组(P<0.01),75μg/mL组的脾脏淋巴细胞转移刺激指数达最高;腹腔巨噬细胞具有一定的吞噬能力,吞噬中性红能力与剂量成依赖关系。结论:复方黄芩颗粒剂在一定程度上有提高小鼠免疫功能的作用。
To study the effect of Compound Radix scutellariae granule on immunologic function of Kunming mice.The test groups were drenched orally with different dosages of compound Radix scutellariae granules. After being drenched orally for ten days ,their thymus-index and spleen-nidex, immune globulins of IgA, IgG, IgM and alexins of C3, C4 of serum were defermined, and experiments in vivo were done. The mice-spleen＇s lymphocytes which were cultured in vivo were added with different concentrations of compound Radix scutellariae granules. The lymphocytes translation stimulate indexes were measured.The ability of licking up neutral red of the peritoneal macrophages cultured in vivo was measured in the groups.The results display that the thymus-index , spleen-nidex, immune globulins of IgA, IgG, IgM and alexins of C3, C4 in the experiment groups were significantly higher than those of the control group （P〈0.05）; the spleen＇s lymphocytes translation stimulate indexes in the experiment groups were higher than that of the control group at a significance level（P〈0.01）. The peritoneal macrophages can enhance the ability of swallowing. The ability of licking up neutral red was depended upon the dosage of drug. Compound Radix scutellariae granule can enhance the immunologic function of mice in some degress.
出处
《江西农业大学学报》
CAS
CSCD
北大核心
2007年第5期809-812,共4页
Acta Agriculturae Universitatis Jiangxiensis
基金
福建省自然科学基金项目(2006J0294)
福建省教育厅资助项目(JB007)
关键词
复方黄芩颗粒剂
昆明小鼠
免疫力
compound Radix scutellariae granule
Kunming mice
immunity
