^(99m)Tc-甲氧基异丁基异腈显像评价肺癌化疗后疗效的研究进展
摘要
自20世纪80年代以来，99m^Tc-甲氧基异丁基异腈（MIBI）被发现能被肿瘤细胞所摄取。因此，国内外学者用99m^Tc-MIBI进行肿瘤显像诊断，以及对其治疗后的疗效评价的研究越来越深入。近年来用99m^Tc—MIBI显像作为评价肺癌化疗疗效的研究，已引起临床肿瘤研究者的关注。
出处
《实用医学杂志》
CAS
2007年第21期3305-3306,共2页
The Journal of Practical Medicine
参考文献16
-
1Akgun A, Cok G, Karapolat I, et al, ^99mTc-MIBI SPECT in prediction of prognosis in patients with small cell lung cancer [J]. Ann Nucl Med, 2006,20 (4) : 269 -275.
-
2Kuwano M, Uchiumi T, Hayakawa H, et al, The basic and clinical implications of ABC transporters, Y-box-binding protein-1 (YB-1)and angiogenesis-related factors in human malignancies [J]. Cancer Sci,2003,94(1 ) : 9-14.
-
3Berger W, Setinek U, Hollaus P, et al. Muhidmg resistance markers P-glycoprotein, multidrug resistance protein 1, and lung resistance protein in non-small cell lung cancer:prognostic implications [J], J Cancer Res Clin Oncol, 2005,131 (6) : 355-363.
-
4Yeh J J,Hsu N Y, Hsu W H,et al. ^99mTc-MIBI SPECT Comparison of chemotherapy response with P-Glycoprotein, muhidrug resistance-related protein-1,and lung resistance-related protein expression in untreated small cell lung cancer [ J ]. Lung, 2005,183 (3) : 177-183.
-
5Furuta M,Nozaki M,Kawashima M, et al. ^99mTc-MIBI scintigraphy for early detection of locally recurrent non-small cell lung cancer treated with definitive radiation therapy [J]. Eur J Nucl Med Mol Imaging, 2003,30 ( 7 ) : 982 -987.
-
6Perek N, Koumanov F, Denoyer D,et al. Modulation of the muhidrug resistance of glioma by glutathione levels depletion interaction with ^99mTc-sestamibi and ^99mTc tetrofosmin [J]. Cancer Biother Radiopharm, 2002,17 (3) : 291-302.
-
7Yuksel M, Cermik T F, Doganay L,et al. ^99mTc-MIBI SPET in non-small cell lung cancer in relationship with Pgp and prognosis [J]. Eur J Nucl Med Mol Imaging, 2002,29 (7) : 876-881.
-
8Joseph B, Bhargava K K, Malhi H, el al. Sestamibi is a substrate for MDR1 and MDR2 P-glycoprotein genes [J]. Eur J Nucl Med, 2003,30(7) : 1024-1031.
-
9Kinuya S, Li X, Yokoyama K,et al. Reduction of ^99mTc-sestamibi and ^99mTc-tetrofosmin uptake in MRP expressing breast cancer cells under hypoxic conditions is independent of MRP function [J]. Eur J Nucl Med mol Imaging, 2003,30( 11 ) : 1529-1531.
-
10Del V S, Zannetti A, Aloj L,et al. Inhibition of early ^99mTc-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma [ J ]. Eur J Nucl Med Mol Imaging,2003,30 (6): 879-887.
-
1焦鲁霞,李亚里,张锦明,田嘉禾.^(99m)Tc-MIBI盆腔显像诊断卵巢恶性肿瘤的临床研究[J].军医进修学院学报,2000,21(1):26-28. 被引量：1
-
2林大任,黄河,李明毅,黄斌豪.乳腺癌^(99m)Tc-MIBI影像与P-糖蛋白表达的相关性[J].中华肿瘤防治杂志,2006,13(9):695-696. 被引量：4
-
3刘保军,李娟.^(99)Tc^m-MIBI乳腺癌显像与P-gp、GST-π及Bcl-2表达的关系[J].宁夏医科大学学报,2009,31(4):435-437. 被引量：1
-
4黄秒,韦智晓,覃伟武,谭晓丹,马加强.^(99m)Tc-MIBI显像对甲状腺单发结节的诊断价值[J].现代肿瘤医学,2010,18(4):674-676. 被引量：2
-
5刘真真,卢振铎,刘慧,李连方,张恒伟,杨辉,李文亮,崔树德.甲氧基异丁基异腈肿瘤显像对可手术乳腺癌新辅助疗效的预测价值[J].中华医学杂志,2011,91(6):382-384. 被引量：3
-
6宋邦坤,杨吉生,沈达炜,马德林,董学先,魏明湘,刘斌,徐燕红.^(99m)Tc-MIBI对甲状腺结节的诊断价值[J].现代医用影像学,1997,6(3):129-130.
-
7孟自力,沈振亚,钱永跃.肺癌^ (99m)Tc-MIBI显像与PGP表达之间的关系[J].苏州大学学报（医学版）,2002,22(4):410-412.
-
8关晏星,雷秋模,熊秋云,杨晓青,张庆,张青,欧阳军,瞿伟.^(99m)Tc-MIBI显像评价乳腺癌新辅助化疗疗效及预后的价值[J].中华肿瘤防治杂志,2009,16(24):1935-1938. 被引量：4
-
9王敏,安秀艳,王思云.常规超声与双核素联合显像鉴别甲状腺结节价值的比较[J].广东医学,2012,33(22):3442-3443. 被引量：4
-
10朱朝晖,周前,李方,李龙芸,崔瑞雪,李龙芸.^(18)F-FDG、^(99)Tc^m-MIBI和^(111)In-奥曲肽对肺癌诊断和治疗评价的比较[J].中华核医学杂志,2001,21(1):20-22. 被引量：5
