期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

芦荟大黄素苷与DNA相互作用的研究 被引量：5

Barbaloin binding to DNA
暂未订购
导出
摘要 目的探讨芦荟大黄素苷与DNA的相互作用。方法采用电子吸收光谱,荧光发射光谱,粘度实验以及凝胶电泳实验进行研究。结果与结论芦荟大黄素以插入方式与DNA分子结合;较高浓度的芦荟大黄素苷能够使Bel-7402肝癌细胞DNA由超螺旋构型转化为缺刻构型。 The binding properties of barbaloin to DNA were investigated by UV-visible electron absorption spectrum, fluorescence emission spectrum, viscosity measurement and gel electrophoresis, and insertion of barbaloin to DNA was identified. Higher concentration of barbaloin could convert DNA configuration of hepatoma carcinoma cell Bel-7402 from superhelix to indention.
作者 韦欣煜 梅文杰 刘云军
机构地区 广东药学院无机化学教研室
出处 《广东药学院学报》 CAS 2007年第5期541-543,546,共4页 Academic Journal of Guangdong College of Pharmacy
基金 广东省博士科研启动项目(04300624) 广东省医学科研基金(B2004069)资助
关键词 芦荟大黄素苷 分子识别 凝胶电泳 DNA barbaloin molecular recognition DNA
分类号 R285 [医药卫生—中药学]
  • 相关文献

参考文献15

  • 1ZONTA F, BOGONI P, MASOTYI P, et al. High performance liquid chromatographic profiles of aloe constituents and determination of aloin in beverages with reference to the EEC regulation for flavouring substances [J]. J Chromatogr A,1995,718:99 - 106.
  • 2GRuN M, FRANZ G. Untersuchungen zur Biosynthese der Aloine in Aloe arborescens Mill [J]. Arch Pharm, 1982, 315:231 -241.
  • 3LEMLI J. Metabolism of sennosides an overview [J]. Pharmacology, 1988,36 (Suppl. 1): 126-128.
  • 4AKAO T, CHE Q M, KOBASHI K, et al. A purgative action of barbaloin is induced by Eubacterium sp. strain BAR, a human intestinal anaerobe of transforming barbaloin to Aloe - emodin anthrone [J]. Biol Pharm Bull, 1996, 19: 136 - 138.
  • 5ISHII Y, TANIZAWA H, TAKINO Y. Studies of aloe. V. Mechanism of cathartic effect [J]. Biol Pharm Bull, 1994, 17:651 -653.
  • 6BROWN J P, DIETRICH P S. Mutagenicity of anthraquinone and benzathrone derivatives in Salmonella/microsome test: Activation of anthraquinone glycosides by enzymic extracts or rat cecal bacterial [J]. Mutat Res, 1979,66:3 - 24.
  • 7KUO P L, LINT C, LIN C C. The antiproliferative activity of aloe-emodin is through P53-dependent and P21-dependent apoptotic pathway in human hepatoma cell lines [J]. Life Sci,2002,71: 1879 - 1892.
  • 8PECERE T, GAZZOLA M V, MUCIGNAT C, et al. Aloe - emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors [J]. Cancer Res, 2000,60:2800 - 2804.
  • 9LEE H Z,HSU S L,LIU MC,et al. Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma[J]. Eur J Pharmacol,2001,431:287 -295.
  • 10WASSERMAN L,AVIGAD S,BEERY E,et al. The effect of aloe emodin on the proliferation of a new Merkel carcinoma cell line Am [J]. J Dermatopathol, 2002,24 : 17 - 22.

同被引文献115

引证文献5

二级引证文献30

广东药学院学报
2007年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部