摘要
目的:研究舌鳞状细胞癌(TSCC)有丝分裂活化蛋白激酶(ERK)基因的表达及其与肿瘤病理分型、临床分期、颈淋巴结转移的关系。方法:采用RT-PCR技术检测45例舌癌组织中ERK1、ERK2mRNA的表达,运用SPSS12.0软件包对数据进行处理,均数比较采用t检验。结果:ERK基因表达强度与TSCC病理分型无关;T3-4期患者ERK基因表达强度显著高于T1-2期患者;TSCC颈淋巴结转移患者,ERK基因表达强度显著高于无转移者。结论:ERK1、ERK2mRNA表达与舌鳞癌的发生、进展和淋巴结转移相关,可作为患者预后的参考指标之一。
PURPOSE： The aim of this study is to investigate the relationship between ERK1, ERK2 gene expression and tumor behavior such as invasion, metastasis in tongue squamous cell carcinoma （TSCC）. METHODS： The expressions of ERK1, ERK2 at gene level were examined in 45 cases of TSCC by reverse transcriptase polymerase chain reaction （RTPCR）. Student＇s t test was used for data analysis using SPSS 12.0 software package. RESULTS： No correlation between the expression intensity of ERK gene and tumor pathological degree of TSCC.A significant relationship was observed between the expression intensity of ERK gene and T stage of TSCC. A significant relationship was observed between the expression intensity of ERK gene and lymphnode metastasis of TSCC. CONCLUSIONS： Activation of ERK gene may play a strong role in cervical lymph node metastasis of TSCC. Intensive expression of ERK may be an important presage marker in TSCC patient. Supported by Key Science and Technology Research Project of Liaoning Province （Grant No. 2005225013 -2）.
出处
《上海口腔医学》
CAS
CSCD
2007年第5期458-460,共3页
Shanghai Journal of Stomatology
基金
辽宁省科技攻关项目(2005225013-2)
