摘要
目的探讨参芪扶正注射液对肺癌小鼠顺铂化疗后免疫功能的影响。方法采用顺铂(DDP)3mg/(kg·d)连续7d腹腔注射建立肺癌小鼠化疗后动物模型。然后随机分为对照组和治疗组,治疗组给予参芪扶正注射液40,80ml/(kg·d)分别腹腔注射给药,连续7d;对照组予生理盐水40ml/(kg·d)。末次给药后24h采用免疫器官重量法检测胸腺指数、脾脏指数;同时采用放射免疫法测定小鼠血清中IL-2和TNF-α的含量。结果治疗组小鼠胸腺指数、脾脏指数均高于对照组(P<0.05);治疗组小鼠血清IL-2水平显著高于对照组,而治疗组TNF-α低于对照组(P<0.05)。结论参芪扶正注射液可提高肺癌小鼠顺铂化疗后的免疫功能,临床上可试用参芪扶正注射液对肺癌化疗后免疫功能低下患者进行治疗。
Objective To investigate the effect of Shenqi Fuzheng Injection on immune function of lung cancer mice after chemotherapy. Methods The lung cancer mice Chemotherapy model was established by abdominal cavity injection of（DDP） with a dose of 3 mg/kg for 7 days, These mice randomly divided into therapy groups and control group, mice in therapy groups were given Shenqi Fuzheng Injection 40 ml/kg and 80 ml/kg per day respectively for 7 days;the control group were given saline 40 mE/kg per day. After 24 h of the last treatment, the immune organ index was evaluated, The levels of IL-2 and TNF-α in mouse serum were measured by RIA. Results There were significant differences in the thymus index and spleen index between the treated groups and control group, It also significant increased the level of IL-2 and decreased the level of TNF-ct in the serum of the lung cancer mice after chemotherapy. Conclusions Shenqi Fuzheng Injection can improve immune function in immunosuppressed mice after chemotherapy and be used clinically for the treatment of immunocompromised patients after chemotherapy.
出处
《实用全科医学》
2007年第11期943-944,共2页
Applied Journal Of General Practice
基金
湖南省科技厅项目(05SK3084)
衡阳市科委项目(2005SK01-017)
关键词
肺肿瘤
化疗
小鼠
免疫功能
参芪扶正注射液
Lung cancer
Chemotherapy
Mice
Immune function
Shenqi Fuzheng Injection
