摘要
目的探讨肿瘤坏死因子-β（TNF-β）＋252基因单核苷酸多态性与胃癌病人癌性恶液质的关系.方法 105例营养不良胃癌病人,按照近6个月体质量的减轻率分成3组：A组,0～5%;B组,6%～10%;C组,〉10%.用PCR结合限制性内切酶检测胃癌病人及110例正常志愿者TNF-β＋252单核苷酸多态性.结果 TNF-β＋252A（TNFB2）出现的频率在胃癌组和对照组差异无显著性（P〉0.05）.在胃癌病人中,TNFB2出现的频率在A、B、C各组差异亦无显著性（P〉0.05）;恶液质病人TNFB2出现的频率与对照组比较差异无显著性（P〉0.05）.结论 TNF-β＋252基因单核苷酸多态性与胃癌恶液质的发生无相关性.
Objective To evaluate the association of TNF-β＋292 mononucleotide polymorphisms with dyscrasia related to gastric cancer. Methods This study was carried out in 105 gastric cancer patients with malnutrition who were divided into three groups according to their weight loss in the last six months： group A, weight loss of 0-5%; group B, 6% 10%; and, group C, 〉10%. The control group consisted of 110 healthy volunteers, The mononeucleotide polymorphisms study was done by Nco I -digested DNA fragment biding PCR. Results No significant differences were found in TNFB2 frequency between the patients and the controls （P2〉0.05）, and between dyserasia group and controls （P〉0.05）. No significant difference was seen in TNFB2 frequency among group A, B and C （P〉0.05）. Conclusion ogenesis of severe dyscrasia.
出处
《青岛大学医学院学报》
CAS
2006年第2期106-107,109,共3页
Acta Academiae Medicinae Qingdao Universitatis
关键词
胃肿瘤
恶病质
多态性
单核苷酸
stomach neoplasms
dyscrasia
polymorphism, TNF-β＋252 polymorphlsm is not associated with the path mononucleotide
