摘要
各型肝病８１例分为慢性迁延性肝炎、慢性活动性肝炎、失偿性肝硬化、重症肝炎和原发性肝癌５组，观察其抗凝和纤溶功能的变化，以血清白蛋白和凝血酶原时间（ＰＴ）作为肝贮备功能的对照指标。结果表明，肝病患者的抗凝和纤溶功能均有显著改变。
The changes in blood anticoagulation and fibrinolysis were investigated in eighty-one patients with various liver diseases including chronic persistent hepatitis (CPH ) , chronic active hepatitis(CAH) , decompensated liver cirrhosis(LC) ,subacute necrosis of liver ( SNL ) and primary liver cancer (PLC ) . Significant changes in blood anticoagulation and fibrinolysis were found in patient groups of various liver diseases , demonstrated by decreased levels of antithrombin Ⅲ activity ( AT Ⅲ , A ) aand antigen ( AT Ⅲ , Ag ) , plasminogen activity (Pg : A ) , plasminogen activator inhibitor act ivity ( PAI : A ) and elevated levels of tissue type plasminogen activator activity ( t-PA : A ) and antigen ( t-PA , Ag ) and a macroglobulin (a- MG ) . Compared to serum albumin and prothromhin time (PT ) , AT Ⅲ, A , PAI , A and Pg , A showed significantly high sensitivities in all groups of the patients and , as well paralleled to the severity of diseases. Further analysis of the relation between hemorrhage risk atnd alteration of coagulation parameters found that decreased AT Ⅲ, A and Pg : A carried a high risk of bleeding complications.
出处
《山东医科大学学报》
1997年第2期138-141,共4页
Acta Academiae Medicinae Shandong
