摘要
溶栓药物可激活纤维蛋白溶酶原形成纤维蛋白溶酶从而加速血栓的溶解。溶栓药物已用于多种血栓性疾病包括急性肺栓塞(PE)、深静脉血栓形成(DVT)和急性心肌梗死等的治疗。本文将讨论PE溶栓治疗的疗效、适应证、禁忌证和不良反应。
出处
《临床急诊杂志》
CAS
2012年第3期222-225,共4页
Journal of Clinical Emergency
参考文献23
-
1THABUT G, THABUT D, MYERS R P, et al. Thrombolytic therapy of pulmonary embolism: a me ta-analysis[J]. J Am Coll Cardiol, 2002,40:1660 - 1667.
-
2GOLDHABER S Z, VISANI L,DE ROSA M. Acute pulmonary embolism: clinical outcomes in the Inter- national Cooperative Pulmonary Embolism Registry (ICOPER) [J]. Lancet, 1999,353 : 1375 -- 1376.
-
3DONG B, JIRONG Y, LIU G, et al. Thrombolytic therapy for pulmonary embolism[J]. Cochrane Data base Syst Rev, 2006,19 : CD004437.
-
4SHARMA G V, BURLESON V A, SASAHARA A A. Effect of thrombolytie therapy on pulmonary-cap- illary blood volume in patients with pulmonary em bolism[J]. N Engl J Med,1980,303..842--845.
-
5SHARMA G V,FOI.I.AND E D,MCINTYRE K M, et al. Long-term benefit of thrombolytic therapy in patients with pulmonary embolism[J]. Vase Med, 2000,5:91--95.
-
6WAN S,QUINLAN D J,AGNELLI G,et al. Throm- bolysis compared with heparin for the initial treat- ment of pulmonary embolism: a meta-analysis of the randomized controlled trials [J]. Circulation, 2004, 110:744--749.
-
7MENEVEAU N, SERONDE M F, BLONDE M C, et al. Management of unsuccessful thrombolysis in acute massive pulmonary embolism[J]. Chest, 2006, 129: 1043--1050,.
-
8DANIELS L B,PARKER J A,PATEL S R,et al. Re- lation of duration of symptoms with response to thrombolytie therapy in pulmonary embolism[J]. Am J Cardiol, 1997,80 : 184-- 188.
-
9Guidelines on diagnosis and management of acute pul- monary embolism. Task Force on Pulmonary Embol- ism, European Society of Cardiology[J]. Eur Heart J, 2000,21:1301-1336.
-
10DALEN J E. The uncertain role of thrombolytic thera py in the treatment of pulmonary embolism[J]. Arch Intern Med,2002,162 : 2521-- 2523.
二级参考文献22
-
1杨永,李义波,侯岩芳,侯新华,孔敬博.急性肺血栓栓塞兔血清BNP变化及辛伐他汀对其影响[J].中国现代医学杂志,2008,18(23):3460-3463. 被引量:5
-
2刘艳梅,翟振国,王辰.肺血栓栓塞症的病理生理学研究进展[J].国外医学(呼吸系统分册),2004,24(5):273-275. 被引量:14
-
3MANN D L.Congestive Heart Failure[M].2nd ed.Philadelphia:Lippincott Williams & Wilkins,2000:213-228.
-
4WAN S,DESMET J M,BARVAIS L,et al.Myocardium is a major source of p roinflammatory cytokines in patients undergoing cardiopulmonary bypass[J].J Thorac Cardiovasc Surg,1996,112(3):806-811.
-
5KAREL KOTASKAA,JANA POPELOVAB,MARIE TIS-EROVAD,et al.The relevance of brain natriuretic peptides investigation in variouscardiovasc-ular diseases[J].Biomed PapMed Fac Univ Palacky Olomouc Czech Repub,2006,150:285-288.
-
6YARDAN T,ALTINTOP L,BAYDIN A,et al.B-type natriuretic peptide as an indicator of right ventricular dysfunction in acute pulmonary embolism[J].Int J Clin Pract,2007.
-
7KRUGER S,GRAF J,MERX M W,et al.Brain natriuretic peptide predicts right heart failure in patients with acute pulmonary embolism[J].Am Heart J,2004,147:60-65.
-
8MA K K,OGAWA T,D E BOLD A J.Selective upregulation ofcardiac brain natriuretic peptide at the transcriptional and translational levels by pro-inflammatory cytokines and by conditioned medium derived from mixed lymphocyte reactions via p38 MAP kinase[J].J Mol Cell Cardiol,2004,36:505-513.
-
9GALIE N MANES A BRANZI A.The endothelin system in pulmonary arterial hypertension[J].Cardiovasc Res,2004,61:227-237.
-
10SILVERSTEIN M D,HEIT J A,MOHR D N,et al. Trends in the incidence of deep vein thrombosis and pulmonary embolishm: a 25 year population-based study[J].Arch Intern Med,1998,158:585 593.
共引文献14
-
1马清艳,刘晖.肺栓塞的诊断现状及进展[J].国际呼吸杂志,2012,32(2):152-156. 被引量:6
-
2常晓,刘燕,王玲,张忠.血必净联合抗凝治疗次大面积肺栓塞的临床观察[J].中国实用医药,2013,8(16):200-201. 被引量:2
-
3高宇,郑峰,叶宏伟,汪易岚.血必净在辅助肺栓塞溶栓治疗中对炎症反应及凝血功能的影响[J].中国实用医刊,2018,45(23):7-11. 被引量:6
-
4窦红杰,胡芳宝,葛广豪,王文,方唯一.心脏型脂肪酸结合蛋白、肌钙蛋白、脑钠肽联合检测对急性肺栓塞危险分层的评估价值[J].中国心血管病研究,2014,12(10):887-891. 被引量:6
-
5李平.抗凝剂联合中医经方治疗肺栓塞的疗效探讨[J].当代医学,2015,21(8):152-153. 被引量:3
-
6韦云威.活血化瘀中药注射剂治疗肺栓塞的研究进展[J].临床合理用药杂志,2015,8(20):178-180. 被引量:6
-
7王海珍,周晶,冯长溪,徐新开.高敏心肌肌钙蛋白I阴性对急性肺栓塞的临床应用价值[J].现代实用医学,2016,28(1):37-38.
-
8王靓,郑云辉.血必净注射液药理研究进展[J].临床医药实践,2016,25(7):542-544. 被引量:39
-
9赵娜,李洋,吴文洋.肌钙蛋白联合血气分析对肺栓塞诊断与危险分层的分析与探讨[J].世界最新医学信息文摘,2017,17(30):68-69.
-
10贺静,常小红.生物标志物在血流动力学稳定的急性肺栓塞危险分层价值[J].临床误诊误治,2018,31(8):105-111. 被引量:2
同被引文献49
-
1孙涛,海波.晕厥为首要表现肺栓塞的临床特点[J].山西医科大学学报,2005,36(1):86-88. 被引量:19
-
2KAHN S, LIM W, DUNN A S, et al. Prevention of VTE in nonsurgical patients. Antithrombotic therapy and prevention of thrombosis, 9th ed.. american college of chest physicians evidence-based clinical practice guidelines[J].Chest, 2012,141: e195S- e226S.
-
3STEVENS S M,DOUKETIS J D. Deep vein thrombo- sis prophylaxis in hospitalized medical patients: cur- rent recommendations, general rates of implementa- tion, and initiatives for improvement[J]. Chin Chest Med, 2010,31 : 675- 689.
-
4SPENCER F A, LESSARD D, EMERY C, et al. Ve- nous thromboembolism in the outpatient setting[J]. Arch Intern Med, 2007,167 : 1471- 1475.
-
5LLOYD N S,DOUKETIS J D, MOINUDDIN I, et al. Anticoagulant prophylaxis to prevent asymptomatic deep vein thrombosis in hospitalized medical patients: a systematic review and meta-analysis[J]. J Thromb Haemost, 2008,6 : 405- 414.
-
6PIAZZA G,FANIKOS J ,ZAYARUZNY M,et al. Ve- nous thromboembolic events in hospitalised medical patients[J]. Thromb Haemost, 2009,102 : 505- 510.
-
7CAPRINI J A, ARCELUS J,SEHGAL L R, et al. The use of low molecular weight heparins for the preven- tion of postoperative venous thromboembolism in gen- eral surgery. A survey of practice in the United States [J]. Int Angiol, 2002,21 : 78- 85.
-
8BARBAR S, NOVENTA F, ROSSETTO V, et al. A risk assessment model for the identification of hospi- talized medical patients at risk for venous thromboem-bolism: the Padua Prediction Score[J].J Thromb Hae- most,2010,8:2450-2457.
-
9DECOUSUS H, TAPSON V F, BERGMANN J F, e* al. IMPROVE Investigators. Factors at admission as sociated with bleeding risk in medical patients: find- ings from the IMPROVE investigators [J]. Chest, 2011,139:69-79.
-
10I KIERKEGAARD A, NORGREN L. Graduated com- pression stockings in the prevention of deep vein thrombosis in patients with acute myocardial infarc- tion[J]. Eur Heart J,1993,14:1365-1368.
引证文献5
-
1王汇.慢性阻塞性肺疾病合并肺栓塞患者的护理[J].解放军护理杂志,2012,29(24):57-58. 被引量:5
-
2石建平,赵梦华,徐宝元.内科住院患者静脉血栓栓塞症的预防[J].临床急诊杂志,2013,14(2):93-96. 被引量:7
-
3石建平,赵梦华,徐宝元.肺栓塞诊断研究进展[J].现代中西医结合杂志,2013,22(30):3418-3420. 被引量:1
-
4朱敏.老年慢性阻塞性肺疾病合并急性肺栓塞的护理[J].当代护士(中旬刊),2015,22(10):20-22. 被引量:4
-
5向芝青,田君华.心电图在急性肺栓塞诊断中的应用价值研究[J].江苏实用心电学杂志,2015,24(3):188-189. 被引量:11
二级引证文献27
-
1吴晓涓.慢性阻塞性肺疾病患者预防并肺栓塞的护理进展[J].世界最新医学信息文摘,2019,0(75):23-24.
-
2李倩.慢性阻塞性肺疾病急性加重合并肺栓塞相关危险因素分析[J].临床肺科杂志,2013,18(12):2256-2257. 被引量:16
-
3赵梦华,石建平,张学强.围术期桥抗凝治疗的研究现状[J].临床急诊杂志,2013,14(12):613-616.
-
4乔峰,吴斗.不同部位的骨折对老年骨折患者围手术期凝血功能的影响[J].中国医药指南,2014,12(20):153-154. 被引量:3
-
5卢朝黎,李宇星.下肢创伤患者术后应用利伐沙班预防静脉血栓栓塞症的疗效及安全性[J].实用药物与临床,2014,17(8):1019-1022. 被引量:6
-
6张胜利,王浩.重症监护病房住院患者发生静脉血栓的风险和预防措施[J].内科急危重症杂志,2015,21(2):118-119. 被引量:7
-
7谭耀坤.慢性阻塞性肺疾病患者预防并发肺栓塞的护理进展[J].右江医学,2015,43(2):248-251. 被引量:8
-
8毛莺燕.心电图在急性肺栓塞中的应用[J].养生保健指南(医药研究),2015,0(22):68-68.
-
9程燕.责任制小组护理模式在溶栓治疗肺血栓栓塞症患者应用价值[J].血栓与止血学,2016,22(1):110-112. 被引量:3
-
10蔡立慧,麦婉萍,吴育兰.急性肺栓塞的临床分析与救治[J].中国现代药物应用,2016,10(14):162-163.
-
1叶小钧,柯元南.脂蛋白A与心肌梗塞[J].中日友好医院学报,1998,12(1):79-82. 被引量:1
-
2姜学义,峰下哲,韩春雷,杨学莉,汪整辉,寇丽筠,王黎曼,杨杰.系统性红斑狼疮患者纤溶功能测定[J].中华皮肤科杂志,1995,28(4):207-209. 被引量:5
-
3江乙.静脉溶栓治疗急性心肌梗死63例观察护理[J].医学文选,2003,22(5):775-777.
-
4李艳芳.组织型纤维蛋白溶酶原激活剂中心给药治疗大块肺栓塞[J].解放军医药杂志,1995,17(1):75-75.
-
5陈春燕,张茂宏,徐从高,刘文兰,苏青,朱媛媛.Svate-3对糖尿病高凝状态的疗效探讨[J].山东医科大学学报,1996,34(3):216-218. 被引量:1
-
6孙学华.Ⅱ型糖尿病62例临床分析[J].现代临床医学,1995,26(4):203-204.
-
7顾玉东,宋后燕.人组织型纤溶酶原激活剂溶栓的实验研究[J].中华外科杂志,1991,29(10):605-607.
-
8鄢盛恺,周新.载脂蛋白(a)研究近况[J].国外医学(临床生物化学与检验学分册),1996,17(1):38-40. 被引量:6
-
9赵继波,姜秀英,杜云珍.10例急性心肌梗塞亚急期静脉溶栓治疗临床观察[J].黑龙江医学,1998,0(1):26-26.
-
10陈春燕,张茂宏,徐从高,侯明,朱媛媛,刘文兰.糖尿病抗凝、纤溶系统的研究[J].山东医科大学学报,1996,34(3):213-216.