摘要
为了探讨慢性病毒性肝炎的发病机理，应用ELISA方法分别对75例慢性过延性肝炎、慢性活动性肝炎、慢性重症肝炎、肝炎后肝硬化患者血清白细胞介素4（IL—4）、白细胞介素6（IL－6）含量进行了检测，同时探讨了IL—6含量变化与血清胆红素水平及凝血酶原活动度的关系，结果表明，各级病人血清IL－4含量与对照组比较无明显差别（P＞0．05）；各组病人中IL－6含量与对照组比较明显升高（P＜0．01），以慢性重症肝炎为最高，说明IL－6在慢性肝炎的发生发展中起一定作用；该组病人共75例，其中IL－6水平与血清胆红素水平呈明显正相关，与凝血酶原活动度（FTA）呈明显负相关，提示IL－6可以反映肝细胞坏死程度，可以做为判断肝脏功能的又一实验室指标。
In order to study the pathology of chronic hepatitis B virus (HBV) disease, interleukin - 4 (IL - 4) and interleukin - 6 (IL - 6) levels were detected using ELISA. The relationship between IL - 6 levels and total bilirubin, PTA was also studied. The results show that the IL - 4 levels in chronic HBV disease patients were not statistically different from the levels in normal subjects (P >0. 05), while the IL - 6 levels in chronic HBV disease patients were significantly higher than in the nomul subjects (P <0. 01). The highest IL - 6 levels were found in the chronic serious HBV disease patients. This suggests that IL - 6 plays an important role in the pathology of chronic hepatitis and hepatic cirrhosis. The IL- 6 and bilirubin levels were found to positively correlate in 75 cases. The IL - 6 and PTA levels negatively correlated. These results suggest that increased levels of IL - 6 and bilirubin indicate the degree of hepatocellular necrosis, and can be used to determine liver function.
出处
《中国现代医学杂志》
CAS
CSCD
1998年第5期9-11,共3页
China Journal of Modern Medicine
关键词
IL-4
IL-6
肝硬化
病毒性肝炎
Interleukin-4
Interleukin-6
Chronic hepatitis B virus
Hepatic cirrhosis
