摘要
目的:探讨术中应用不同剂量的曲马多对雷米芬太尼复合全麻苏醒期镇痛的影响。方法:60例ASAⅡ￣Ⅲ级静吸复合全麻下行下腹部肿瘤手术(包括结肠癌、直肠癌)的患者随机分为3组:Ⅰ组曲马多1.0mg/kg、Ⅱ组曲马多2.0mg/kg、Ⅲ组曲马多3.0mg/kg。各组分别于术毕前40min静注给药。手术结束后滞留30min,观察患者苏醒恢复期的清醒时间、拔管时间和拔管后0min、20min的平均动脉压、心率及镇痛(VAS)评分和并发症(恶心、呕吐、嗜睡、呼吸抑制等)。结果:Ⅱ组和Ⅲ组的VAS评分显著低于Ⅰ组(P<0.01)。清醒时间、拔管时间和拔管后平均动脉压、心率的差异无显著性(P>0.05)。Ⅲ组的恶心、呕吐发生率较高。结论:雷米芬太尼复合全身麻醉术中,曲马多应用剂量以2.0mg/kg为好。
Objective：To compare the effects of 3 different doses of tramadol on pain in the early recovery period after remifentanil-based anesthesia. Methods：Sixty patients undergoing fire operation on subabdominal tumor under remifentanil-based anesthesia were randomly assigned to receive intravenous injection of tramadol of 1.0 mg/kg in group Ⅰ, 2.0 mg/kg in group Ⅱ, and 3.0 mg/kg in group Ⅲ 40 minutes before fire end of the operation. The wake-up time, extubation time, and mean arterial pressure, heart rate, pain level evaluated by the Visual Analogue Scale （VAS）, and incidence of complications within 20 minutes after extubation were recorded. Results： Compared to group Ⅰ, the VAS pain scores were significantly lower in groups Ⅱ and Ⅲ （P 〈 0.01 ）, no significant differences in wake-up time, extubation tinle, and mean arterial pressure and heart rate after extubation were found. The incidences of nausea and vomiting in group Ⅲ were higher than those in other 2 groups. Conclusion： The appropriate dose of tramadol is 2.0 mg/kg in fire early recovery period after remifentanil-based anesthesia.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2007年第5期604-605,607,共3页
Journal of China Medical University
