摘要
目的:探讨术中氟比洛芬酯与曲马多复合应用对全麻苏醒期镇痛的影响。方法:80例ASAⅡ～Ⅲ级静吸复合全麻下行下腹部肿瘤手术(包括结肠癌、直肠癌)的患者随机分为四组:Ⅰ组曲马多1.0mg/kg、Ⅱ组氟比洛芬酯1.0mg/kg、Ⅲ组曲马多2.0mg/kg、Ⅳ组曲马多1.0mg/kg+氟比洛芬酯1.0mg/kg。各组分别于术毕前40min静注给药。手术结束后滞留30min,观察患者恢复质量(清醒时间、拔管时间和拔管后收缩压、舒张压、心率及疼痛评分)及并发症(恶心、呕吐、嗜睡、呼吸抑制等)。结果:Ⅲ组和Ⅳ组的疼痛评分显著低于Ⅰ组和Ⅱ组(P<0.05)。清醒时间、拔管时间和拔管后收缩压、舒张压、心率的差异无显著性(P>0.05)。Ⅲ组的恶心、呕吐发生率较高。结论:术中复合应用氟比洛芬酯与曲马多不但全麻苏醒期镇痛效果好,而且并发症发生率低。
Objective：To compare the analgesic effect of flurbiprofen axetil with tramadol in resuscitation stage after general anesthesia.Methods：Eighty patients were recruited into the study and divided into four groups： group Ⅰ（n=20） received tramadol 1.0mg/kg,group Ⅱ（n=20） received flurbiprofen axetil 1.0mg/kg,group Ⅲ （n= 20） received tramadol 2.0mg/kg,group Ⅳ（n=20） received flurbiprofen axetil 1.0mg/kg and tramadol 1.0mg/kg. Forty minutes before the end of surgery,each group was intravenous administered in all patients.Pain scores, heart rate,blood pressure and incidence of side effect were recorded after tracheal extubation.Results＇Pain scores were significantly lower in group Ⅲ and group Ⅳcompared to group Ⅰ and group Ⅱ （P〈0.05）.The inci- dence of nausea and vomiting in group Ⅲ was higher than that in the other groups.Conclusion：Flurbiprofen axetil with tramadol can effectively analgesia in the resuscitation stage after general anesthesia,with less side reactions.
出处
《中日友好医院学报》
2007年第2期85-87,共3页
Journal of China-Japan Friendship Hospital
关键词
氟比洛芬酯
曲马多
镇痛
flurbiprofen axetil
tramadol
analgesia
