摘要
目的探讨永嘉县氟中毒未成年人血清碱性磷酸酶水平的变化情况。方法选择2012年4月至2013年4月永嘉县入院检查诊断为氟中毒的未成年人共67例作为氟中毒组,按照1∶1对照方案选择同年龄、同性别的入院体检的健康儿童67例作为对照组,比较2组受试者血清碱性磷酸酶的水平。结果不同年龄阶段氟中毒儿童血清碱性磷酸酶水平均显著高于对照组儿童(P<0.05);将ALP>500 U/L作为异常,本研究共检出异常者8例,其中氟中毒组检出异常7例,异常率为10.45%,对照组检出异常1例,检出异常率为1.49%,2组比较,差异具有统计学意义(P<0.05)。结论氟中毒儿童其血清碱性磷酸酶活性有所增加,血清碱性磷酸酶升高对儿童氟中毒所致骨损伤具有着重要的意义。
Objective To probe into the changes of serum alkaline phosphatase（ ALP） level of juvenile with fluorosis in Yongjia County. Methods Sixty-seven cases of juvenile with fluorosis that were diagnosed in our hospital were selected as fluorosis group. Sixty-seven healthy teenagers at same age and with same gender whose physical examination was conducted in our hospital were selected as control group. The serum alkaline phosphatase level of subjects was compared. Results Serum alkaline phosphatase level of juvenile with fluorosis at different ages was significantly higher than that of control group（ P 0. 05）. The indicators of ALP 500 U / L was considered as abnormal,8 cases were found as abnormal,7 abnormal cases were found in the fluorosis group with the rate of 10. 45%; 1 abnormal cases were found in the control group with the rate of 1. 49%. The result of the two groups were compared（ P 0. 05）. Conclusion The activity of serum alkaline phosphatase of juvenile with fluorosis was increased,the increase of ALP plays an important role in bone injury of juvenile caused by fluorosis.
出处
《中国地方病防治》
2014年第1期60-61,共2页
Chinese Journal of Control of Endemic Diseases
基金
永嘉县科技计划项目
