摘要
为进一步了解食管癌变发生的分子学基础，采用免疫组织化学方法测定人食管鳞癌组织中癌基因Ｒａｓ蛋白的表达。结果：在３６例食管癌手术切除标本中，９例出现免疫阳性反应，免疫阳性反应率为２５％；同时还发现同一食管癌组织中食管粘膜固有腺体上皮也出现免疫阳性反应，其表达强度高于鳞状上皮。提示：Ｒａｓ基因表达是食管癌变晚期阶段的一个分子学改变。
To further understand the molecular basis of esophageal carcinogenesis and its development, ras oncogene protein expression was determined in the tissues of human esophageal squamous cell carcinoma with immunohistochemical method. Results: ras protein immunoreactivity was observed in 9 of the 36 surgically resected esophageal cancer specimens, accounting for 25%, and at the same time, positive immunoreactivity of ras protein was also observed from submucosa gland epithelium of the same esophageal specimen. The immunoreactivity in the submucosa gland was stronger than that in the esophageal cancer tissue. The present studies indicated that the ras gene protein expression was one of the molecular changes in the late stage of esophageal carcinogenesis.
出处
《河南医科大学学报》
1997年第1期43-45,共3页
Journal of Henan Medical University
基金
国家自然科学基金
国家教委留学回国人员专项基金
河南省首批杰出青年科学基金
关键词
食管肿瘤
鳞癌
RAS
癌基因
esophageal squamous cell carcinma
oncogene
ras
