摘要
采用免疫组织化学（ＡＢＣ）法检测食管癌高发区５５例食管和贲门癌组织中肿瘤抑制基因ｍａｓｐｉｎ的表达。结果表明，食管癌组织中ｍａｓｐｉｎ免疫阳性表达率为１０％（３／３０），免疫阳性反应主要位于癌组织的细胞浆中；贲门癌组织中ｍａｓｐｉｎ免疫阳性表达率为２４％（６／２５），免疫阳性反应主要位于癌组织的细胞核中。提示：肿瘤抑制基因ｍａｓｐｉｎ可能在食管和贲门癌变过程中起一定的作用。
The expression of tumor supressor gene maspin protein was determined in 55 subjects with esophageal and gastric cardia cancer from a high incidence area of esophageal cancer with the immunohistochemical method(ABC).The results showed that the positive immunostaining rate of maspin protein was 10%(3/30)and 24%(6/25)in esophageal and gastric cardia cancer respectively,and the immunoreactivity of maspin protein was chiefly located in the cytoplasm and nuclear respectively.The present results indicated that tumor suppressor gene maspin played a role in esophageal and gastric cardia carcinogenesis.This concept need to be confirmed by further studies.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1999年第1期1-2,共2页
Cancer Research on Prevention and Treatment
基金
国家自然科学基金
