摘要
木脂素类化合物是自然界中普遍存在的一类物质,具有抗肿瘤,抗炎,抗病毒,保肝及抑制血小板活化因子(PAF)等生理功能。随着植化分离手段和结构鉴定方法的提高,先进的药物高通量筛选技术之广泛应用,越来越多的该类化合物和相关生物活性被相继报道。作者从芳基萘,二苄基丁内酯,四氢呋喃,二苄基丁烷,联苯环辛烯,新木脂素等6个方面对这类化合物的生物活性进行总结,旨在促进对木脂素类化合物的研究和开发。
Lignans are widely existed in natural world with a variety of structures and bioactivities,including anti-tumor,anti-inflammatory,anti-viral and hepatoprotective properties.Along with the development of new techniques in phytochemistry and application of advanced drug screening methods,a variety of lignans have been identified and their bioactivities revealed.In this review,we summarized the activities of six different types of lignans,including arylnaphthalene,dibenzylbutyrolactone,tetrahydrofuran,dibenzylbutane,dibenzocyclooctadiene and neolignan,in order to provide an updated overview of this research field.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第20期2089-2094,共6页
China Journal of Chinese Materia Medica
基金
国家重点基础研究发展规划973课题(2004CB518902)
关键词
木脂素
生物活性
芳基萘
二苄基丁内酯
lignans
bioactivity
arylnaphthalene
dibenzylbutyrolactone
