摘要
目的:研究糖尿病(DM)患者听力损失特点,探讨其听性脑干反应(ABR)和畸变产物耳声发射(DPOAE)变化特征。方法:对在我院就诊的136例(272耳)DM患者(实验组)的一般情况、有无微血管并发症及听力损失程度等进行问卷调查,按每10岁分为30～40岁,>40～50岁,>50～60岁,>60～70岁4个年龄段,均对其进行纯音听阈(PTT)、声导抗、ABR和DPOAE检测,并与120例(240耳)同样分为4组的正常同龄成人(对照组)进行比较。结果:实验组30～40岁年龄段其ABRⅠ～Ⅴ波间期及反应阈与对照组比较差异无统计学意义,40岁以上患者ABR反应阈随增龄明显增加、波间期延长,而且60岁以上患者Ⅲ～Ⅴ、Ⅰ～Ⅴ波间期的延长与同龄对照组比较差异有统计学意义(P<0.05)。实验组与对照组患者的DPOAE检出率均为100%,但早期DM患者DPOAE幅值在1～8kHz均较同龄对照组降低,且以4kHz幅值减小明显,变化差异有统计学意义(P<0.05)。结论:DM患者多为双侧渐进性的轻、中度听力损害,ABR及其听阈异常与患者年龄、性别及有无微血管并发症相关,而与DM类型及病程无关。DPOAE可用于了解早期DM患者的耳蜗损害。
Objective：To study the characteristic of hearing loss and the changes of the auditory brainstem response and distortion product otoacoustic emission in diabetics. Method：General information of 136 diabetics were investigated whether had the complication of capillary vessel and hearing loss with self-made questionnaire at random. 136 cases （272 ears） were tested with ABR and DPOAE. They were divided into A,B,C,D four groups according to the age of per ten years （30-70 years）. Other 120（240 ears） matched healthy adult were enrolled in the control group. The pure tone threshold （PTT）,acoustic impedance,ABR and DPOAE results were compared between the four groups and the control group, and then made statistical analysis. Result： When comparing to the control group, the interpeak latency Ⅰ- Ⅴ and ABR response were no significant difference between patients at the stage of 30 years. Not only the threshold of wave Ⅴ was elevated with aging in patients over 40 years, but the amplitude of the peak latencies of waves Ⅲ and Ⅴ were lessening, and the interpeak latency Ⅲ- Ⅴ and Ⅰ - Ⅴ were prolonged between patients at the stage of 60 years, which had significant difference compared with agematched patients（ P 〈0.05）. The inducing rate of DPOAE were 100% in the test and control group, but the amplitude of DPOAE declined ranged from 1 to 8 kHz in patients with early diabetes mellitus and were significantly reduced at 4 kHz, which had significant difference compared with age-matched patients（ P 〈0.05）. Conclusion： The majority of patients with diabetes mellitus had slight and moderate hearing loss gradually. The ABR and the threshold of ABR response were varied with the age and sex of patients, and whether had the complication of capillary vessel, but were not related to its type and disease course. The DPOAE can comprehend the cochlear disorder in patients with early diabetes mellitus.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2007年第19期875-879,共5页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词
糖尿病
聋
诱发电位
听觉
脑干
耳声发射
自发性
Diabetes mellitus
Deafness
Evoked potentials, auditory, brainstem
Otoacoustic emission, spontaneous
