摘要
对46例非胰岛素依赖性糖尿病患者及40例正常人的血小板聚集功能及血浆凝血酶原时间、凝血酶时间、活化部分凝血活酶时间进行测定。了解其在糖尿病血管病变发生中的作用,并探讨其影响因素。结果表明:糖尿病组血糖、尿糖控制基本稳定后,血小板聚集功能仍明显高于对照组,而且这种改变出现于微血管病变之前。磺脲类药物对血小板聚集的抑制作用不明显,而小剂量巴米尔可使血小板聚集功能恢复正常。糖尿病组的凝血酶原时间、凝血酶时间和活化部分凝血活酶时间,与对照组相比差异无显著性。
Platelet aggregation function, PT,TT and APTT were measured in 46 patients with NIDDM and 40 healthy individuals to research on their action and influence factors in diabetic angiopathy. The results showed that after normalization of blood and urine sugar, platelet aggregation function in diabetic group was still higher than that in control group,and that platelet aggregation function had been increased before microaogiopathy occurring in diabetic group. Inhibition of platelet aggregation function by sulfonylureas drugs was limited, and low dosage of aspirin could normalize platelet aggregation function. There were no obvious differences in PT, TT and APTT between diabetic group and control group.
出处
《天津医药》
CAS
1997年第5期272-274,共3页
Tianjin Medical Journal
关键词
血小板聚集
糖尿病
微血管病变
NIDDM
platelet aggregation function diabetic microangiopathy non-insulin-dependent diabetes mellitus
