摘要
为研究胃癌侵袭性和根治手术对患者血清透明质酸浓度的影响,通过应用酶联免疫吸附方法(ELISA)测定20例胃,8患者血清透明质酸(hyaluronic acid,HA)浓度,结果发现,胃癌组明显高于对照组(P<0.001),BorrmannⅢ、Ⅳ组或伴有淋巴结转移组分别显著高于Borrmann Ⅰ、Ⅱ组或无淋巴结转移组(P<0.001),切除瘤体后上述各组的HA均显著下降(P<0.01～0.001)。结果提示,血清HA可能与胃癌的浸润和转移密切相关。
Using ELISA, the fasting concentration of serum hyaluronic acid (HA) was measured in 20 patients with gastric cancer before and after radical operation. The average HA level of cancer group was much higher than that of healthy control group (P<0. 001). Among 20 cases the HA concentration in Borrmann Ⅲ,Ⅳgroup and lymphy node metastasis was significantly higher than that in Borrmann Ⅰ,Ⅱ and lymphy nodes metastasis groups, respectively. The HA level was dramatically decreased (P<0.001) in all groups after the incision of tumors. The results suggest that serum HA may be an indication associated with the infiltration and metastasis of gastric cancer.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1997年第3期136-137,共2页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金资助
关键词
透明质酸
肿瘤转移
胃肿瘤
外科手术
hyaluroic acid
tumor infringement
gastric cancer
surgical operation
