摘要
目的：本文通过检测20例胃癌病人的组织TGFβ1mRNA水平和血清TGFβ1浓度．旨在探讨TGFβ1与胃癌浸润和转移是否相关。方法：应用酶联免疫吸附法测定胃癌病人血清转化生长因子（TGF）β1浓度；应用点杂交法和计算机灰度扫描分析组织的TGFβ1mRNA水平。结果：胃癌原发灶组的TGFβ1mRNA灰度均值明显高于癌旁对照组（P＜0．001），浸润组或伴有淋巴结转移组分别明显高于膨胀组或无淋巴结转移组（P＜005）；血清TGFβ1浓度变化与组织TCFβ1mRNA表达具有明显的正相关性（r＝0792，P＜005）结论：TGF6可能与胃癌的浸润和转移密切相关。
Purpose: To detect relationship between transforming growth factor β1 (TCFβ1 ) and the invasive and metastatic Potential of gastic carinomas. level of TCFβ1 messenger RNA (mHNA ) from tissue and level of serum TGFβ1 in 29 patients suffering from gastric carcinoma were determined in our study . Method: Concetration of serum TGFβ1 and the gremy value of tissue TGFβ1 mRNA were analyzed. by ELISA or Dot Blot and Computer scanning. respeletively. Results: The gremy value of TGFβ1mRNA was much higher (P < 0. 001 ) in group of gastric cancer than that of control tissue near to the tumour. and it was also significant ability (P < 0. 05 ) ill groups. with invasive ability or with metaslatic lymphy nodes than those of groups. with expanding growth or without metastatic lymphy nodes respectively Moreover. values of serum TGFβ1 were positively correlated with those of tissue TGFβ1mRNA (r = 0. 792. P < 0. 05 ). Conclusions: 'TGFβ1 may be a factor associated with the invasive and metastatic potential of gastric carcinomas.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1999年第2期156-158,共3页
Chinese Journal of Cancer
基金
国家自然科学基金!39570786
关键词
胃肿瘤
转化生长因子
肿瘤转移
TGFΒ1
Gastric neoplasrns: Transforming growth factor: Tumor aggressiveness
