摘要
目的:进一步了解前列腺特异性抗原(PSA)、游离前列腺特异性抗原(FPSA)与总前列腺特异性抗原(TPSA)比值(FPSA/TPSA)的测定在诊断前列腺癌的临床价值。方法:采用化学发光免疫分析法(CLIA)对前列腺癌患者57例,前列腺增生患者147例血清PSA、FPSA和FPSA/TPSA在各组中的改变情况及取不同界值时对前列腺癌的诊断意义。结果:在诊断灰区外高值区,TPSA、F/T在两组间的差别均有显著性意义(P<0.05,P<0.05);在诊断灰区患者间TPSA差别无显著性意义(P>0.05),而F/T值的差别有显著性意义(P<0.05);在灰区外低值区TPSA、F/T值在两组间差别无显著性意义(P>0.05)。如果以血清PSA值4 ng/ml为阈值,诊断前列腺癌的灵敏度为100%,特异性为52.6%,如果以血清PSA 4 ng/ml为阈值,同时结合FPSA/TPSA并以16为阈值,诊断前列腺癌的灵敏度为100%,而特异性为87.5%。结论:PSA与FPSA联合检测可以提高对前列腺癌诊断的特异性。
Objective：To evaluate serum TPSA and F/T ratio in the differential diagnosis of BPH and PCa.Methods： Serum TPSA,FPSA and F/T ratio in 147cases of BPH and 57 cases of PCa were assessed and evaluated both in patients within and outside the＂gray zone＂. Results： TPSA and F/T ratio were both significantly discriminating between benign and malignant diseases （P〈0.05, P〈0.05）,when the assessed values were much higher beyond the ＂gray zone＂ ;When the as- sessed values were within the＂gray zone＂,TPSA couldn＇t be a differential marker for the 2 conditions（P〉0.05）, whereas F/T ratio could（P〈0.05）;however, in lower value range beyond the ＂gray zone＂,neither TPSA nor F/Tratio could specificly diffentiate the two （P〉0.05）.In case of PSA 4.0 ng/ml,the sensitivity of PCa was 100%,the specificity 52.6%.In case of PSA 4.0 ng/ml and FPSA/TPSA16, the sensitivity of PCa was 100%,the specificity 87.6%.Conclusion： Using of PSA and FPSA can improve the diagnostic specificity of prostatic cancer.
出处
《中国医药导报》
CAS
2007年第10Z期99-100,共2页
China Medical Herald
关键词
前列腺特异性抗原
前列腺癌
Prostate specific antigen
Prostatic cancer
