摘要
目的探讨脑热清(NRQ)口服液的解热机制。方法复制内生致热原性发热家兔模型,观察NRQ对体温的影响,并利用放射免疫法检测下丘脑及脑脊液cAMP的含量。结果NRQ对家兔内生致热原性发热有显著的解热作用(P<001);能够明显降低下丘脑及脑脊液中cAMP的含量(P<001)。相关分析显示,4组家兔的体温变化与下丘脑cAMP含量呈明显正相关(r=0899,P<001);下丘脑与脑脊液cAMP含量变化亦呈显著正相关(r=0971,P<001)。结论抑制下丘脑和脑脊液中cAMP含量的升高,可能是脑热清的解热机制之一。
AIM: To investigate the antipyretic mechanism of Naoreqing (NRQ) oral liquid, a Chinese medicine. METHODS: ① Fever models of rabbits were established by intravenous. injection of endogenous pyrogen (EP). ② The antipyretic action of NRQ were observed. ③ cAMP contents in the hypothalamus (HP) and the cerebrospinal fluid (CSF) were determined by radioimmunoassay. RESULTS: ① NRQ obviously reduced body temperature of febrile rabbits induced by EP (P<0.01). ② Reversed contents of cAMP in HP and in CSF were observed (P<0.01). ③ Correlation analysis indicated that contents of cAMP (r=0.899, P<0.01) in HP were positively correlated with the change of body temperature in rabbits. The contents of cAMP in HP also correlated with those in CSF (r=0.971,P<0.01). CONCLUSION: NRQ may exert its antipyretic effect in rabbits by inhibiting the increase in content of cAMP in HP and CSF. [
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2005年第1期172-174,共3页
Chinese Journal of Pathophysiology
基金
北京市科委资助课题(No.954024200)
