摘要
目的:考察靛玉红及其磷脂复合物和自乳化释药系统在犬体内的药动学过程。方法:采用三周期交叉试验设计法,取6条健康beagle犬随机分成3组,分别服用剂量为100mg的靛玉红片、靛玉红磷脂复合物和靛玉红自乳化释药系统,用高效液相色谱(HPLC)法测定靛玉红的血药浓度,利用3P97软件包和统计矩方法计算主要药动学参数和相对生物利用度。结果:以靛玉红片为对照,靛玉红磷脂复合物和自乳化释药系统的相对生物利用度分别为(157±s 10)%和(162±16)%。结论:磷脂复合物和自乳化释药系统有利于改善靛玉红口服生物利用度。
AIM： To study the pharmacokinetic behavior and the relative bioavailability of indirubin, indirubin phytosome and indirubin self-emulsifying drug delivery system （SEDDS） in beagle dogs. METHODS： The plasma concentrations of indirubin were determined by HPLC method following a separated single oral dose of 100 mg of indirubin, its phytosome and SEDDS given to 6 dogs in an open randomized three-periodic crossover design. The computer software package 3P97 and the statistical moment method were used to calculate the pharmacokinetic parameters and the relative bioavailability. RESULTS： Compared with indirubin tablets, the relative bioavailability of indirubin phytosome and indirubin SEDDS was （157 ± s 10） % and （162 ± 16） % respectively. CONCLUSION ： Phytosome and SEDDS are in favor of improving oral bioavailability of indirubin.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2007年第9期646-648,共3页
Chinese Journal of New Drugs and Clinical Remedies
