摘要
目的研究当归油自乳化制剂最佳处方组成和比例。方法用溶解性实验、正交筛选和伪三相图法研究当归油自乳化释药系统的制备,通过评价当归油自乳化制剂处方的乳化效果和乳滴粒径大小,优选最佳的处方。结果当归油自乳化释药系统的处方组成为当归油、中碳链甘油三酯、聚氧乙烯蓖麻油时,能获得较好的自乳化效果。结论当归油自乳化释药系统的最佳处方为中碳链甘油三酯与聚氧乙烯蓖麻油的质量比为7∶3、当归油质量分数为45.5%。
Objective To investigate the optimum formula of self-emulsifying drug delivery system （SEDDS） angelica oil. Methods Solubility experiments, orthogonal screen, and a pseudo-ternary phase diagram were used for the preparation of SEDDS angelica oil. The optimum formula was determined by the emulsification degree and emulsion particle size. Results The best effect of emulsification was achieved when the formula was composed of angelica oil, Crodamol GTCC as oil phase, and Cremophor EL as the nonionic surfactant. Conclusion The optimum formula for SEDDS angelica oil is： Crodamol GTCC and Cremophor El. （the proportion is 7 ： 3）, and angelica oil （wt% is 45.5%）.
出处
《现代药物与临床》
CAS
2009年第6期350-353,共4页
Drugs & Clinic
关键词
当归油
自乳化
伪三相图
最佳处方
angelica oil
self-emulsifying
pseudo-ternary phase diagram
optimum formula
