摘要
目的:研究油茶树嫩枝挥发油的皮肤毒性及对尼群地平、黄芩苷、尼美舒利等药物的促透效果。方法:通过活体大鼠皮肤毒理实验和离体小鼠皮肤渗透释药实验,评价皮肤毒性并测定不同浓度挥发油对尼群地平、黄芩苷、尼美舒利的促透效果。结果:不同剂量挥发油均无皮肤刺激性、致敏性和急性毒性,对尼群地平、黄芩苷、尼美舒利的透皮吸收促进效果明显,其作用接近或超过氮酮。结论:油茶树嫩枝挥发油无皮肤毒性,并具有明显的透皮吸收促进作用。本实验的研究结果将为新型天然透皮促进剂的研究开发提供一定的科学依据。
Objective： To study the toxicity on skin and penetration effect of volatile oil from tender branchers of Camellia oleifera on nitrendipine, baicalin, nimesulide for percutaneous obsorption. Method： Acute skin toxicity, irritation and allergy on rats were tested, and mouse skin in vitro was applied for studying the effects of different concentrations of volatile oil in nitrendipine, baicalin, nimesulide on drug permeation. Result： Different dosage volatile oil had no acute toxicity, irritation or hypersensitive effects. Compared to azone, more powerful enhancement effects of volatile oil at different concentration on nitrendipine, baicalin, nimesulide were very obvious. Conclusion： This paper firstly reported the results of experiment about the toxicity to skin and penetr-ation effect of volatile oil from tender branches of C. oleifera.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第17期1780-1783,共4页
China Journal of Chinese Materia Medica
基金
浙江省教育厅科研项目(20050325)
关键词
油茶树
挥发油
毒理
透皮促进作用
嫩枝
大鼠
Camellia oleifera
volatile oil
toxicology
penetration enhancement of skin absorption
tender branchers
rat
