摘要
代谢综合征(MS)是一个长期客观存在的临床问题,对其定义、发病机制和治疗也一直存有争议。MS的本质是什么?究竟是一种病抑或几种危险因素的聚集仍有不同认识。近年许多研究揭示腹型肥胖是MS的最重要特征,脂肪病变和胰岛素抵抗是其关键的病理生理改变,动脉粥样硬化性心血管病是其主要的临床后果,干预腹型肥胖能有效地控制MS及其并发病。虽然MS存在多种形式,但如将其视为一个与肥胖相关的代谢性心血管综合征,或许对其本质的理解和临床实践更有启示作用。
Metabolic syndrome （ MS）, as a clinical issue, has been proposed for over half a century. However, no consensus on its definition, pathogenesis and treatment has been reached so far. What is the entity of MS？ Whether it is one kind of disease or constellation of several risk factors has been argued. Recent studies have shown that abdominal obesity is the most important feature of MS, which is linked with adipose tissue dysfunction and insulin resistance. Atherosclerotic cardiovascular disease is the main clinical outcome of MS. Thus, intervention of abdominal obesity is a key target for controlling MS and its complications. Although MS is composed of multiple subtypes, it is helpful for us to understand its entity and guide the clinical practice if we regard MS as an obesity-related cardiometabolic syndrome.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2007年第4期291-293,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
代谢综合征
腹型肥胖
心血管疾病
Metabolic syndrome
Abdominal obesity
Cardiovascular diseases
