摘要
糖尿病大血管病的致病因素复杂。虽然糖尿病与动脉粥样硬化性心血管病关系密切，但两者发病机制有所区别。近年的临床试验表明仅强化降糖治疗难以减少心血管事件，必须结合降压和调脂等综合干预措施。要有效防止糖尿病对大血管的进行性损害，必须全面评估其血管病变的特征及危险性大小，干预得越早和越及时，就越有助于阻断高血糖诱发的代谢记忆与血管并发症，干预策略应注重危险因素的全面控制、治疗方法的协调平衡及个体化。
Etiology of diabetic macrovascular disease is complex. Although diabetes is closely associated with atherosclerotic cardiovascular diseases （ ASCVD ）, their pathogeneses are different. Recent clinical trails showed that multiplex intervention including anti-hyperglycemia in combination with lipids adjusting and blood pressure lowering procedures significantly reduced the events of ASCVD, but intensive gljcemic control alone did not. To prevent the ongoing diabetic macrovascular lesion, comprehensive evaluation of macrovascular damage and risks is very important. In addition, early treatment of hyperglycemia will blockade the hyperglycemia-induced metabolic memory and ameliorate vascular complications. Management of diabetic macrovascular disease should emphasize the strategy of simultaneously modifying all of the risk factors, harmonious equipoise of intervention and tailoring treatment.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2009年第4期361-365,共5页
Chinese Journal of Endocrinology and Metabolism
关键词
糖尿病
大血管病变
干预策略
Diabetes mellitus
Macrovascular diseases
Management strategy
