摘要
目的观察氯胺酮在治疗士的宁惊厥时对兔呼吸、循环的影响。方法健康成年家兔50只,雌雄不拘,随机分成K1.25、K2.5、K5.0、NS和PB5.0组,每组10只。清醒状态局部麻醉作用下行股动脉插管、剑突穿线,测定兔股动脉血压和呼吸频率。兔耳缘静脉注射士的宁0.25 mg/kg制作惊厥模型,强直惊厥出现后立即静脉注射治疗药物。观察各组兔的死亡数、强直持续时间、呼吸频率和股动脉血压情况。结果氯胺酮大、中、小3个剂量组与NS组和PB5.0组相比,兔强直持续期明显缩短（P〈0.01）,且呈剂量依赖性（r=-0.8696,P〈0.05）。K2.5、K5.0和PB5.0组死亡均为零。氯胺酮各剂量组呼吸频率在注药后2-5 min内比基础值提高（P〈0.01）。氯胺酮各剂量组股动脉血压在注药后2、5 min时高于PB5.0组（P〈0.05）,在5、10 min时高于NS组（P〈0.05）。结论氯胺酮能对抗士的宁诱发的惊厥,明显改善惊厥兔的呼吸、循环。
Objective To observe the effects of ketamine （K） on respiration and circulation during its therapeutic use against drug - induced convulsion in rabbits. Methods Fifty rabbits of both sexes were randomly divided into K1.25 （mg/kg）, K2.5 （mg/kg）, K5. 0 （mg/kg）, NS （0.5 ml/kg） and PB5.0 （phenobarbital, 5.0 mg/kg） groups. Convulsion was induced with intravenous strychnine （0.25 mg·kg^-1） within 15 seconds. Drug treatment was administered intravenously once convulsion occurred. Convulsant latency, duration of tonic state, mortality, rate of respiration and femoral artery blood pressure were noted. Results Ketamine could dose - dependently shorten the duration of tonic state induced by strychnine （ P 〈0.05, r =0. 8696）. The mortality was 4/10 in the NS group and zero in the K2.5, K5. 0 and PBS. 0 groups. The varied doses of ketamine stimulated the depressed respiration for 2 - 5 rain （ P 〈 0.01 ）. The femoral artery blood pressure was higher in the K groups than in the NS and PB5. 0 groups （ P 〈 0.05）. Conclu- sion Ketamine can antagonize the strychnine - induced convulsion and improve the respiration and blood pressure in the convulsive rabbits.
出处
《徐州医学院学报》
CAS
2007年第8期491-494,共4页
Acta Academiae Medicinae Xuzhou
基金
江苏省高校自然科学基础研究项目(07KJD310219)
徐州医学院院课题(07KJ29)
关键词
氯胺酮
抗惊厥
呼吸
血压
ketamine
anti - convulsion
respiration
circulation
