摘要
目的:观察枳椇子提取物(Semen Hoveniae extracts,SHE)对大鼠实验性肝纤维化的防治作用并探讨其作用机制。方法:采用CCl4诱导大鼠肝纤维化模型,设正常对照组、模型组、阳性对照组、SHE低、中、高各剂量组。通过测定大鼠血清中Ⅲ型前胶原(PC-Ⅲ)、层粘蛋白(LN)、透明质酸(HA),并作肝组织病理学形态分析反映肝纤维化的损伤程度。结果:SHE低、中、高各剂量组均能显著改善肝功能,降低PC-Ⅲ、LN、HA水平,组织学检查也显示其具有抗纤维化作用。结论:SHE在体内具有抗大鼠实验性肝纤维化作用,有望用于肝纤维化的防治。
Objective：To investigate the prevention and treatment of experimental liver fibrosis in rats by Semen Hoveniae extracts （SHE）. Methods：Rats liver fiborsis model was induced by carbon tetraehloride（ CCl4 ）. SD rats were randomly divided into six groups： the normal control group,the model control group, the positive control group and the SHE groups. The level of serum proeollgan type-Ⅲ （Pc-Ⅲ） ,hyaluronic acid （HA）, laminin （LN） and liver function were measured, respectively. Liver histological examination was made. Results ： SHE could ameliorate CCl4-induced liver fibrosis significantly. The lever of serum PC- Ⅲ , HA, LN decreased and liver function was improved. The histological examination also demonstrated its anti-fibrotic effect. Conclusion：SHE have anti-fibrotic effect on liver in vivo,and may have potential value for clinical use.
出处
《中药材》
CAS
CSCD
北大核心
2008年第10期1550-1552,共3页
Journal of Chinese Medicinal Materials
关键词
枳惧子
肝纤维化
Semen Hoveniae
Liver fibrosis
