摘要
目的考察黄芩苷葡萄糖注射液与黄芩苷氯化钠注射液的安全性,观察黄芩苷静脉注射后产生的急性毒性反应和死亡情况。方法通过豚鼠过敏试验、家兔溶血试验和血管刺激性试验,以及小鼠急性毒性实验来考察制剂安全性。结果豚鼠过敏试验、家兔溶血试验和血管刺激性试验均显阴性,小鼠急性毒性实验测得黄芩苷注射液LD50为2.7354±0.2588g/kg。结论黄芩苷类注射剂具有较好的安全性。
Objective To examine the safety of baicalin glucose injection and baicalin sodium chloride injection and observe the acute toxic reaction and death status after intravenous injection of baicalin. Methods Examined the safety of preparation via the sensitivity test of guinea pig, hemolysis test and blood vessel irritation test of rabbit as well as mouse acute toxicity test. Results The sensitivity test of guinea pig, hemolysis test and blood vessel irritation test of rabbit all showed negative results. The baicalin injection LD50 was 2. 7354 ±0. 2588g/kg determined via the mouse acute toxicity test. Conclusions The baicalin injection is comparatively safe.
出处
《医学研究杂志》
2007年第7期15-21,共7页
Journal of Medical Research
基金
浙江省中医药卫生科技计划项目(2003C130)
杭州市重大科技发展计划项目(2003123B19)
杭州市医药卫生重点项目(2004Z006)
杭州市131优秀中青年科技培养人才项目资助
关键词
黄芩苷
安全性实验
急性毒性实验
Baicalin
Safety experiment
Acute toxicity experiment
