摘要
目的评价放射治疗同期应用L-OHP联合5-Fu/LV治疗直肠癌术后局部复发患者的疗效及毒副作用。方法2000年5月至2003年6月对收治的38例术后局部复发直肠癌患者，在放射治疗的同期应用L-OHP联合5-Fu/LV治疗3-6个周期：放疗期间化疗2个周期，放疗后继续化疗1-4个周期，放疗剂量为60-68Gy/7周，并进行回顾性分析。结果1、2、3年生存率分别为84%、61%、37%；1、2、3年局部控制率分别为65%、53%、45%，同时其治疗相关不良反应有所增加，但大部分为1、2级，未见4级治疗不良反应发生。治疗失败的原因为肿瘤远处转移及局部复发。结论放射治疗的同期应用L-OHP联合5-Fu/LV治疗直肠癌术后复发是1种安全、有效的治疗模式。
Objective To evaluate the efficacy and toxicities of concurrent radio - chemotherapy of oxaliplatin with 5 - flurouracil and leucovorin in postoperative local recurrent colorectal carcinoma. Methods 38 patients with postoperative local recurrence from colorectal carcinoma were treated with radiotherapy and oxaliplatin, 5 - flurouracil and leucovorin. 3 to 6 cycles of chemotherapy were given, in which 2 cycle were used concurrently with radiotherapy and 1 - 4 cycles were given after concurrent radiochemotherapy. The dose of radiotherapy was 60 - 68 Gy in 7 weeks. Results The overall 1 -, 2 -, and 3 - year survival rates were 84%, 61%, and 37%. The overall 1 -, 2 -, and 3 -year local control rates were 65%, 53%, and 45%. Treatment related toxicities were increased, but there were no grade Ⅳ side effects. The main causes of treatment failure included distant metastasis and local recurrence. Conclusion Concurrent radiochemotherapy with oxaliplatin, 5 -flurouracil and leucovorin was effective and safe in the treatment of postoperative local recurrent colorectal carcinoma.
出处
《实用癌症杂志》
2007年第4期391-392,400,共3页
The Practical Journal of Cancer
关键词
直肠癌
放疗
化疗
Rectal carinoma
Radiotherapy
Chemotherapy
