摘要
目的:探讨甲地孕酮在治疗晚期非小细胞肺癌化疗中的作用。方法:46例晚期非小细胞肺癌患者,随机分为治疗组与对照组,治疗组24例采用M-NP方案[MA(甲地孕酮)NVB(长春瑞滨)加PDD(顺铂)联合的化疗方案],和对照组22例采用单纯NP方案[NVB(长春瑞滨)加PDD(顺铂)联合的化疗方案]治疗,两组患者均以每4周为1个周期,观察两组患者的疗效,消化道反应,骨髓抑制及生活质量。结果:两组患者客观疗效(CR+PR)分别为50%及45.5%,无显著性意义(P>0.05),两组消化道反应,骨髓抑制及生活质量改善情况间差别均有显著性意义(P<0.05),未见甲地孕酮引起的不良反应发生。结论:甲地孕酮配合NP方案和单纯NP方案治疗晚期非小细胞肺癌的客观疗效无明显差异性,但前者毒副反应小,患者生活质量改善明显。
Objective：To investigate the effect of megestrol acctate（MA） in patients with advanced non-small cell lung cancer.Methods：Forty-six cases with advanced non-small cell lung cancer were randomly divided into two groups：24 cases in trial group were treated with M-NP regimen;22 cases in the control group treated with NP alone.Both regimens were repeated every 4 weeks.The changes of gastrointestinal reactions,bone narrow function and quality of life of patients in each group were observed.Results：The objective response rate（CR＋PR） was 50% in trial group compared to 45.5% in control group（P〉0.05）.The gastrointestinal reactions bone narrow functions and QOL were improved significantly in trial group compared to control group（P〈0.05） there was no adverse effects induced by MA.Conclusion：M-NP regimen had lower toxicity,and better QOL than NP regimen alone for advanced non-small cell lung cancer,however there was no significant statistical difference in the objective response rate between the two groups.
出处
《现代肿瘤医学》
CAS
2007年第10期1432-1434,共3页
Journal of Modern Oncology
关键词
甲地孕酮
长春瑞滨
顺铂
非小细胞肺癌
生活质量
megestrol acetate
NVB
cisplatin
non-small cell lung cancer
quality of life
