摘要
目的:研究大鼠肝移植最适麻醉方法和观察各种输注液体对肝移植受体无肝期中、后阶段血液动力学的影响。方法：300只雄性SD大鼠进行150例肝移植，观察供受体麻醉过程、麻醉药物剂量及其效果；80只雄性SD大鼠，分为供受体两组，受体组再随机分为对照组C，生理盐水组G1，NaHCO3组G2，丹参组G3，每组10只。无肝期开始补液，观察各生理指标变化。结果：供体氯胺酮麻醉的剂量以100～150mg／kg为宜。从上腔静脉给予生理盐水、NaHCO3和丹参8ml／h均对体温无显著影响，但均明显改善无肝期血液动力学。NaHCO3可使无肝期末pH值较对照组有较大的提高，对PO2、PCO2及SatO2无明显的影响，但使术后再灌注期的肝功能有较显著改善。丹参能提高无肝期末动脉PO2，并相应降低PCO2，使再灌注后肝功能有显著改善。结论：受体麻醉术前使用阿托品可显著降低术后肺部并发症发生率。无肝期补液能纠正该期血液动力学紊乱。丹参液可作为首选。
This experiment focused on the choice of proper anesthesia drug and its dosage,and the study of the effect of infusion in recipient anhepatic period on various physiological indexes. Methods:We analysed donor and recipient anesthesia procedure, dosage and effect after having performed 150 trans-plants using 300 rats- Eighty SD species rats were divided into two groups, donor and recipient. The latterwas divided into four subgroups, control group C with no infusion in anhepatic peri0d, physical salinegroup G,,NaHCO3 solution group G, and salvia miltiorrhiza solution group G, in dosage of 8 ml/h via supe-rior vena cava catheter in anhepatic period- Infusion begoan at anhepatic period t0 observe changes of physi-ological index. Results: Ketamine dosage of donor analgesia was 100~ 150 mg/kg of choice- Infusion ofsaline, NaHCO3, and salvia miltiorrhiza solution in dosage of 8 ml/h via superior vena cava catheter in an-hepatic period could markedly ameliorate hemokinetics at the end of this period with no significant affectionto body temperature- NaHCO3 could raise pH value compared with control and ameliorate liver functioneven in postoperative reperfusion period while have no obvious effect on PO2, PCO, and SatO23. Salvia mil-tiorrhiza solution could make PO2 higher and PCO2 lower relatively at the end of anhepatic period as well asimprove liver function after reperfusion. Conclusion: Atropine im before recipient operation can markedlyreduce the morbidity of lung infection. Infusion in anhepatic period can c0rrect hemodynamical disorders.Salvia miltiorrhiza solution is of choice.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1997年第1期20-23,共4页
Academic Journal of Second Military Medical University
关键词
肝移植
麻醉
药物剂量
无肝期
补液
orthotopic liver transplantation
anesthesia
administration dosage
anhepatic period
infusion therapy
