摘要
以香草醛为原料，经甲醚化，氧化和Ｃｌａｉｓｅｎ缩合，合成了相应的β酮酸酯，再经改进的Ｋｎｏｒ反应，实现β酮酸酯的偶联，通过环化、选择性氢化还原等反应，成功地合成了去甲二氢愈创木酸（ｎｏｒｄｉｈｙｄｒｏｇｕａｉａｒｅｔｉｃａｃｉｄ）；呋喃愈创木酚二甲醚（ｆｕｒｏｇｕａｉａｃｉｎｄｉｍｅｔｈｙｌｅｔｈｅｒ）和二氢愈创木酸二甲醚（ｄｉｈｙｄｒｏｇｕａｉａｒｅｔｉｃａｃｉｄｄｉｍｅｔｈｙｌｅｔｈｅｒ）。
β Keto ester(5) was obtained from vanilin through etherification, oxidation and condensation with acetoacetic ester, (5) on oxidative coupling reaction by NaOEt/I 2 produced dimer (6) in high yield. Acid catalyzed cyclodehydration of (6) gave the furan derivative(7), and by a series of selective hydrogenation nordihydroguaiaretic acid, furoguaiacin dimethyl ether and dihydroguaiaretic acid dimethyl ether were synthesized.
出处
《药学学报》
CAS
CSCD
北大核心
1997年第4期278-281,共4页
Acta Pharmaceutica Sinica
关键词
抗氧剂
甲二氢愈创术酸
NDGA
合成
Nordihydroguaiaretic acid
Furoguaiacin dimethyl ether
Dihydroguaiaretic acid dimethyl ether
