摘要
目的:利用鹌鹑饵食性高脂血症模型研究黄花倒水莲总皂苷的调脂作用。方法:连续给予鹌鹑35d高脂饲料,形成高脂血症模型,停止高脂饲料喂养,分别给予黄花倒水莲总苷(PTS)25、50、100mg.kg-1;阳性药辛伐他汀2mg.kg-135d。分别于给药前和给药后35d测定血清中TC,TG,HDL-C,LDL-C和SOD活性,MDA,NO含量,取肝组织测定TC,TG含量。结果:造模35d后血清中TC,TG和LDL-C及MDA,肝组织中TC,TG含量升高,血清中HDL-C和NO含量和SOD活性降低。结论:PTS能降低血清中TC、TG和LDL-C及MDA,肝组织中TC、TG,升高血清中HDL-C和NO含量和增强SOD活性。
AIM： To study the lipid regulation effects of PTS in quails fed with high lipid diet. METHODS： Quails were fed with high fatty diet for consecutive 35 days as hyperlipidmia model. Quails administered with different doses （25, 50, 100 mg· kg^-1 ） of PTS and quails administered with Simvastatin as the positive control for 35 days. The concentration of TC （ total cholesterol）, TG （ triglyceride）, low-density lipoprotein cholesterol （LDL-C）, high-density lipoprotein cholesterol （HDL-C） and NO in serum before and after administration were determined. The concentration of TC,TG in liver have also been determined. RESULTS： After 35 days the concentration of TC,TG,LDL-C, NO and MDA in serum of quails, TC,TG in liver increased, while HDL-C and the activity of SOD in serum decreased. CONCLUSION： PTS can decrease semm＇s TC, TG, LDL-C in serum. It oppositely increases the serum HDL-C,NO and activity of SOD.
出处
《中国天然药物》
SCIE
CAS
CSCD
2007年第4期289-292,共4页
基金
中国中医药管理局新药基金(NoDZX021A)~~
关键词
黄花倒水莲
皂苷
高脂血症
Polygala aureocauda Dunn
Saponins
Hyperlipidmia
