摘要
以３种动物模型研究了血脂康的降血脂作用。将２５％酪蛋白加入家兔基础饲料中，６０ｄ后血清ＴＣ从１．８１ｍｍｏｌ／Ｌ升至７．５１ｍｍｏｌ／Ｌ，则内源性高胆固醇血症模型建立；血脂康０．４，０．８ｇ·ｋｇ￣（－１）·ｄ￣（－１）治疗性给药３０ｄ后，有显著降低血清ＴＣ浓度和ＴＣ／ＨＤＬ－Ｃ比值（０．８ｇ．ｋｇ￣（－１）·ｄ￣（－１））的作用（Ｐ＜０．０５）。将０．５％胆固醇，１５％蛋黄粉，５％猪油加入家兔基础饲料中，可形成外源性高脂血症模型；同时预防性ｐｏ血脂康０．８９．ｋｇ￣（－１）·ｄ￣（－１）后，服药家兔血清ＴＣ、ＴＧ浓度和ＴＣ／ＨＤＬ－Ｃ比值明显降低（Ｐ＜０．０５），且有抑制主动脉粥样硬化斑块形成和脂质在肝脏沉积的作用。将１％胆固醇，１４％猪油，６％豆油加入鹌鹑基础饲料中，２周后可形成外源性高脂血症模型；同时预防性ｐｏ血脂康０．１，０．２，０．４ｇ．ｋｇ￣（－１）·ｄ￣（－１）后，可显著降低血清ＴＣ、ＴＧ（Ｐ＜０．０５或Ｐ＜０．０１）的浓度。此结果证实了血脂康在降血脂及预防动脉粥样硬化方面的药理作用。
We studied that the effects of Xuezhikang on blood lipids and lipoprotein concentra-tions of three kinds of animal models. In rabbits fed on a diet of 25%casein ( hyperc-holesterolaemia induced endogenously ), serum cholesterol concentration increased from approxi-mately 1. 81 to 7. 51 mmol/L within 60 days. Treatment with Xuezhikang for 30 days at doses of0.4,0.8g· kg￣(-1)·d￣(-1) significantly lowered serum TC concentration and TC/HDL-C ratio(P<0. 05). In rabbits , in which hyperlipidaemia was induced exogenously by a atherogenic diet of0.5%cholesterol , 15% yolk powder,5%lard,oral Xuezhikang 0.89·kg￣(-1)·d￣(-1) for 40 days re-duced serum TC , TG concentrations and TC/HDL-C ratio (P<0. 05 ). Moreover, lesions in theaortae and lipidosis in the livers of Xuezhikang-treated rabbits were less severe than those of thecontrol model rabbits. In quails ,in which hyperlipidaemia was induced exogenously by anathero-genic diet of 1% cholesterol, 14% lard,6% soya-bean oil, oral Xuezhikang 0.1,0. 2 and 0.4g· kg￣(-1)·d￣(-1) for 2 weeks reduced serum TC and TG concentrations(P<0. 05 or P<0.01).Theresults of this study demonstrate that Xuezhikang reduces serum TC,TG concentrations of rab-bits and quails with experimental hyperlipidaemia and suppresses atherosclerosis by an athero-genic diet.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1995年第11期656-660,共5页
Chinese Pharmaceutical Journal
