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幽门螺杆菌CagA及其致病机理的研究进展 被引量:1

H.pylori Cag A gene and its pathogenesis mechanism in digestive diseases
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出处 《胃肠病学和肝病学杂志》 CAS 2007年第3期298-300,共3页 Chinese Journal of Gastroenterology and Hepatology
关键词 幽门螺杆菌 细胞毒性相关蛋白 胃癌 XU Shunfu(the First Affiliated Hospital, Nanjing Medical University, Nanjing 210000, China)
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  • 1周建嫦,张建中,徐采朴,何利华.幽门螺杆菌cagA长度多态性及其临床意义[J].解放军医学杂志,2005,30(12):1046-1048. 被引量:5
  • 2Hirata Y,Yanai A,Shibata W,et al.Functional variability of cagA gene in Japanese isolates of Helicobacter pylori[J].Gene,2004.343(1):165-72.
  • 3Azuma T,Yamazaki S,Yamakawa A,et al.,Association between diversity in the Src homology 2 domain--containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer[J].J Infect Dis,2004,189 (5):820-827.
  • 4Argent RH,Kidd M,Owen RJ,et al.,Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori[J].Gastroenterology,2004,127 (2):514-23.
  • 5Yamaoka Y,Kodama T,Kashima K,et al.Variants of the 3 ' region of the cagA gene in Helicobacter pylori isolates from patients with different H.pylori-associated diseases[J].J Clin Microbiol,1998,36 (8):2258 -2263.
  • 6Higashi H,Yokoyama K,Fujii Y,et al.EPIYA motif is a membranetargeting signal of Helicobacter pylori virulence factor CagA in mammalian cells[J].J Biol Chem,2005,280(24):23130-23137.
  • 7Kim SY,Lee YC,Kim HK,et al.Helicobacter pylori CagA transfection of gastric epithelial cells induces interleukin-8[J].Cell Microbiol,2006,8(1):97-106.
  • 8Odenbreit S,Puls J,Sedlmaier B,et al.,Translocation of Helicobacter pylori CagA into gastric epithelial cells by type Ⅳ secretion[J].Science,2000,287 (5457):1497-1500.
  • 9Higashi H,Tsutsumi R,Muto S,et al.,SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein[J].Science,2002,295(5555):683-668.
  • 10Higashi H,Tsutsumi R,Fujita A,et al.Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites[J].Proc Natl Acad Sci U S A,2002,99(22):14428-14433.

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