摘要
目的：预测医院制剂呋喃西林麻黄碱滴鼻液的稳定性，为临床提供贮存期依据。方法：采用经典恒温加速法，分别在５５，６５，７５，８５℃恒温条件下，在不同间隔时间内用紫外分光光度法测定呋喃西林的含量。结果：其稳定性与温度有关，符合Ａｒｈｅｎｉｕｓ公式。结论：本制剂在室温（２５）时贮存期为８０．８ｄ。
OBJECTIVE:To estimate the stability of furacillin and ephedrine nasal drops,which will be considered as the base of storage life for clinic use.METHODS:Classic isothermal accelerated tests were used at 4 different temperatures of 55,65,75,85℃.Samples were taken at certain time intervals and the content of furacillin was determined using UV spectrophotometer.RESULTS:The stability of furacillin was related to the temprerature which was in consistent with Arrhenius equation.CONCLUSION:Under the condition of room temperature(25℃) the storage life of furacillin was about 80.8 d.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1997年第3期150-151,共2页
Chinese Pharmaceutical Journal
关键词
呋喃西林
滴鼻液
稳定性
呋麻滴鼻液
classic isothermal accelerated tests,furacillin,nasal drops,stability
