摘要
组织培养制备的狂犬病毒灭活疫苗与重组白细胞介素２同时免疫ＢＡＬＢ／ｃ鼠和Ｓｗｉｓｓ鼠，检测不同时间的鼠血清中抗病毒ＩｇＧ抗体和中和抗体效价。结果显示：在白细胞介素２的作用下，抗体产生的时间提前，抗体效价提高（Ｐ＜０．０１），ＢＡＬＢ／ｃ鼠和Ｓｗｉｓｓ鼠比较，前者的抗体效价更高（Ｐ＜０．０１）。狂犬疫苗与白细胞介素２联合免疫后ＮＫ细胞杀伤活性显著提高，达５１．３７％（Ｐ＜０．０１），特异性细胞毒性Ｔ细胞（ＣＴＬ）活性的二次反应显著加强（Ｐ＜０．０１）。
In determining whether the interleukin2(IL 2) could be an adjuvent to increase the immune response of mouse to inactivated radies virus vaccine.BALB/c mice and Swiss mice were divided equally into two groups respectively.They were immunized by the inactivated rabies virus vaccine with IL 2 or without IL 2,and detected for anti virus IgG antibody and virus neutralizing antibody after vaccination.The results showed that the anti virus IgG antibodies and virus neutralizing antibodies had appeared 5 days earlier for the group with IL 2 than the one without IL 2.The antibody titer had raised much higher for the group with IL 2 than another one.Similarly,as an adjuvent,the IL 2 was able to increase the cellular immune response to the vaccine.CBA/J mice were immunized some vaccine and IL 2,the activity of nature killer cells(NK)and the activity of specific cytotoxic T lymphocytes(CTL)reached a high level,they were 51.3±6.7% and 29.1±3.0%,respectively.
出处
《免疫学杂志》
CAS
CSCD
北大核心
1997年第1期23-25,共3页
Immunological Journal
关键词
狂犬疫苗
白细胞介素2
细胞免疫
Inactivated rabies virus vaccine,IL 2,Virusneutralizing antibody,Cellular immune
