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microRNAs在血液细胞分化及相关肿瘤中的作用 被引量：4

Roles of microRNAs in Hematopoietic Cell Differentiation and the Related Tumors
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摘要 microRNAs（miRNAs）是一类普遍存在的长度约为21-25个核苷酸的小分子RNA，通过与靶mRNA3^＋端非编码区互补结合在转录后水平抑制靶基因的表达。血细胞形成是一个包括多个基因有序的开启和关闭，复杂而又精密的调控过程，调控异常会导致各种血液病的发生。miRNA参与了造血调控并与某些血液系统肿瘤的发生相关。 They regulate gene atopoiesis is one of MicroRNAs （miRNAs） are a family of 21-25 nucleotide small nonprotein-coding RNAs. expression at post-transcriptional level by mRNA the most important highly regulated multistage p degradation or translation repression. Hemrocess, which includes orderly turn-on and turn-off of many genes; any wrong modulation may result in blood diseases. Several miRNAs have been found to be involved in hematopoiesis and hematopoietic tumor genesis.
作者 杨桂花 王芳 张俊武
机构地区 中国医学科学院北京协和医学院基础医学研究所医学分子生物学国家重点实验室
出处 《中国医学科学院学报》 CAS CSCD 北大核心 2007年第3期425-429,共5页 Acta Academiae Medicinae Sinicae
基金 国家自然科学基金(30570389)~~
关键词 MIRNAS 血细胞分化 血液系统肿瘤 microRNA hematopoitic cell differention hematopoietic tumors
分类号 Q522 [生物学—生物化学]
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参考文献33

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同被引文献102

  • 1潘秋卫,蔡荣,刘新垣,钱程.microRNA与肿瘤发生、诊断及治疗[J].自然杂志,2006,28(2):84-87. 被引量：6
  • 2Wei Liu Sheng-Yong Mao Wei-Yun Zhu.Impact of tiny miRNAs on cancers[J].World Journal of Gastroenterology,2007,13(4):497-502. 被引量：18
  • 3徐卫,李建勇.MicroRNA与淋巴增殖性疾病[J].国际病理科学与临床杂志,2007,27(1):1-5. 被引量：2
  • 4高杰,杨彤涛,裘秀春,鱼兵,韩建伟,范清宇,马保安.成骨肉瘤细胞SOSP-9607中miRNA的克隆与验证[J].癌症,2007,26(6):561-565. 被引量：16
  • 5高佳莉,罗玉萍,李思光.miR-34基因家族的分子进化[J].Zoological Research,2007,28(3):271-278. 被引量：13
  • 6Wang JF , Zhou H , Chen YQ , et al . Identification of 20 microRNAs from Oryza sativa. Nucleic Acids Res, 2004 , 32:1688- 1695.
  • 7Berezikov E, Guryev V, van de Belt J,et al. Phylogenetie shadowing and computational identification of human microRNA genes. Cell, 2005,20: 21-24.
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  • 9Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA, 2004, 101:2999- 3004.
  • 10Meister G, Tuschl T. Mechanisms of gene silencing by double-stranded RNA. Nature,2004,431: 343-349.

引证文献4

二级引证文献4

中国医学科学院学报
2007年 第3期

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