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MicroRNA与淋巴增殖性疾病 被引量：2

MicroRNA gene expression in lymphoproliferative disorders
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摘要 在动植物基因组中广泛存在一类非编码蛋白的小RNA,即microRNA(miRNA)。miRNA在肿瘤的形成和转录后调节基因表达中起重要作用。miR-15a和miR-16-1表达水平的改变与慢性淋巴细胞白血病(CLL)有关,原癌基因bcl-2可能是miR-15a和miR-16-1的靶基因;活化B细胞型弥漫性大B细胞淋巴瘤(DLBCL)、儿童Burkitt淋巴瘤等肿瘤细胞miR-155的拷贝数明显增高,认为miR-155表达水平可以作为DLBCL诊断和预后的重要指标;miR-17-92簇(miR-15a,miR-16-1,miR-155,miR-17-92cluster,miR-142)是一组可能的肿瘤相关基因。 Plant and animal genomes contain an abundance of small genes, known as microRNAs （ miRNAs）, which play an important role in the pathogenesis of tumors and negatively regulate the expression of protein-encoding genes at the post-transcriptional level. The miR-15a-miR-16-1 cluster is frequently deleted and/or downregulated in the majority of CLL cases, miR-15 and miR-16 induce apoptosis by targeting BCL2. High expression of precursor miR-155 was detected in activated B cell phenotype diffuse large B cell lymphoma （DLBCL） and Burkitt＇ s lymphoma （BL）. The miR-155 level may be useful diagnostically and prognostically in DLBCL. The miR-17-92 cluster （miR-15a, miR-16-1, miR-155,miR-17-92 cluster, miR-142） acts as an oncogene under one set of conditions and as a tumor suppressor under another.
作者 徐卫 李建勇
机构地区 南京医科大学第一附属医院
出处 《国际病理科学与临床杂志》 CAS 2007年第1期1-5,共5页 Journal of International Pathology and Clinical Medicine
基金 江苏省135工程医学重点人才基金(RC2002044)~~
关键词 MIRNA 淋巴增殖性疾病 发病机制 miRNA lymphoproliferative disorders pathogenesis
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献31

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二级参考文献22

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共引文献15

同被引文献52

  • 1杨桂花,王芳,张俊武.microRNAs在血液细胞分化及相关肿瘤中的作用[J].中国医学科学院学报,2007,29(3):425-429. 被引量：4
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引证文献2

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国际病理科学与临床杂志
2007年 第1期

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