摘要
To observe the effects of phenylallyl compounds on prostaglandin E2（PGE2）release in mouse cerebral microvascular endothelial cells （bEnd.3） stimulated by IL-1β, and to analyze their structure-activity relationship. Different concentrations of phenylallyl compounds were added separately, and the content of PGE2 induced by IL-1β in the culture media was measured by ELISA assay. The 50% inhibitory concentration （IC 50 ） of PGE2 was calculated. Studies showed that phenylallyl compounds could affect the PGE2 release differently in bEnd.3 cells induced by IL-1β. Close relationships were shown between the inhibitory activities and the location and number of the substituent groups. In conclusion, phenylallyl compounds exhibited inhibitory activities at different extent on PGE2 release in bEnd.3 cells stimulated by IL-1β and presented certain structure-activity relationship.
To observe the effects of phenylallyl compounds on prostaglandin E2 （PGE2 ）release in mouse cerebral microvascular endothelial cells （bEnd. 3） stimulated by IL-1β, and to analyze their structure-activity relationship. Different concentrations of phenylallyl compounds were added separately, and the content of PGE2 induced by IL-1β in the culture media was measured by ELISA assay. The 50% inhibitory concentration （IC50） of PGE2 was calculated. Studies showed that phenylallyl compounds could affect the PGE： release differently in bEnd. 3 cells induced by IL-1β. Close relationships were shown between the inhibitory activities and the location and number of the substituent groups. In conclusion, phenylallyl compounds exhibited inhibitory activities at different extent on PGE2 release in bEnd. 3 cells stimulated by IL-1β and presented certain structure-activity relationship.
出处
《药学学报》
CAS
CSCD
北大核心
2007年第7期798-802,共5页
Acta Pharmaceutica Sinica
基金
国家自然科学基金重大项目(90209006)
关键词
苯丙烯类化合物
前列腺素E2
构效关系
脑微血管内皮细胞
白介素1
桂枝汤
phenylallyl compounds
prostaglandin E2
structurecactivity relationship
cerebral microvascular endothelial cell
interleukin-1
Guizhi decoction
